The relationship between oxidative stress and inflammation according to COVID-19 severity.

Identifier:  TFG:9020

Handle: https://hdl.handle.net/20.500.11797/TFG9020

Authors:  Ruiz Annakim, Salma

Abstract:
SARS-CoV-2 infection leads to varied COVID-19 severity, closely linked to inflammation and oxidative stress. While severe cases often show higher inflammation, the exact correlation between Reactive Oxygen Species (ROS) levels and inflammation across different severity degrees has been unclear. A study of 42 COVID-19 patients (mild, moderate, severe) analyzed plasma for pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) and Total Oxidant Status (TOS). Severe patients exhibited significantly elevated IL-6, IL-1β, and TOS. No direct correlation was found between these cytokines and TOS. However, TOS and IL-6 correlated positively with age and weight, with IL-6 also higher in males. These markers significantly correlated with other clinical parameters, confirming severe COVID-19 involves increased inflammation and oxidative stress, influenced by demographic factors.