Lyophilized Maqui (Aristotelia chilensis) improves carbohydrate metabolic markers and insulin sensitivity in high fat diet-induced obese mice but not when supplemented with a normal diet in healthy mice

Entity: Universitat Rovira i Virgili (URV)

Confidenciality: No

Education area(s): Nutrició i Metabolisme

APS: No

Title in different languages: El maqui liofilitzat (Aristotelia chilensis) millora els marcadors metabòlics de carbohidrats i la sensibilitat a la insulina en ratolins obesos induïts per una dieta alta en greixos, però no quan es complementa amb una dieta normal en ratolins sans.

Abstract: Anthocyanidins found Maqui berry (Aristotelia chilensis) ameliorates insulin sensitivity. Healthy male C57BL/6J mice (n = 51) of 4 weeks were randomly divided into 4 experimental groups: control group (CTL) with normal diet and filtered water, control group (CTLM) with normal diet supplemented with maqui (20 mg of freeze-dried maqui/mL in water), high-fat diet (HFD) group, high-fat diet supplemented with maqui (HFDM) group. Maqui increased the expression of Glut4 and Chrebpα/β in the scWAT of mice fed in a HFDM but not in CTLM. This proves polyphenols improve insulin sensitivity more in an altered metabolism than when consumed by healthy individuals.

Subject: Metabolisme

Academic year: 2023-2024

Language: en

Work's public defense date: 2024-06-20

Subject areas: Health sciences

Student: Castillo Serrato, Carmen

Department: Bioquímica i Biotecnologia

Creation date in repository: 2025-05-19

TFM credits: 18

Keywords: Polyphenols, Anthocyanins, Insulin Resistance

Title in original language: Lyophilized Maqui (Aristotelia chilensis) improves carbohydrate metabolic markers and insulin sensitivity in high fat diet-induced obese mice but not when supplemented with a normal diet in healthy mice

Access Rights: info:eu-repo/semantics/openAccess

Project director: Relat Pardo, Joana