Autor segons l'article: López de las Hazas M., Piñol C., Macià A., Romero M., Pedret A., Solà R., Rubió L., Motilva M. Carme Piñol; Alba Macià; María-Paz Romero; Rosa Solà; Laura Rubió; Maria-José Motilva
Departament: Medicina i Cirurgia
Autor/s de la URV: PEDRET FIGUEROLA, ANNA, SOLÀ ALBERICH, ROSA MARIA
Paraules clau: Hydroxytyrosol Microbial catabolism Metabolic pathways
Resum: This study investigated and compared the absorption, metabolism, and subsequently, the tissue distribution and excretion of hydroxytyrosol (HT) administered either in its free form or through its naturally occurring esterified precursors, namely oleuropein (OLE) and its aglycone forms known as secoiridoids (SEC). Here, rats were fed a diet supplemented with the equivalent of 5 mg phenol/kg/day for 21 days and the HT metabolites in the gastrointestinal digesta (stomach, small intestine and caecum), plasma, urine and metabolic tissues (liver and kidney) were analysed. Compared to HT and SEC, OLE showed greater stability during digestion, and, consequently, the bioavailability based on the urine excretion of HT metabolites was higher. OLE, as a glycoside molecule, reached the colon unaltered generating more diverse microbial metabolites. In terms of bioavailability, findings suggest that OLE might be the most suitable precursor of HT for incorporation into foods or nutraceutical formulations.
Grup de recerca: Unitat de Recerca de Lípids i Arteriosclerosi
Àrees temàtiques: Ciències de la salut Ciencias de la salud Health sciences
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1756-4646
Identificador de l'autor: N/D; N/D; N/D; N/D; N/D; N/D; N/D; N/D
Data d'alta del registre: 2016-04-19
Pàgina final: 63
Volum de revista: 22
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S1756464616000335
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1016/j.jff.2016.01.030
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Pàgina inicial: 52
Tipus de publicació: Article Artículo Article