Articles producció científica> Ciències Mèdiques Bàsiques

Virulence and resistance to antifungal therapies of Scopulariopsis species

  • Dades identificatives

    Identificador: PC:1513
    Handle: https://hdl.handle.net/20.500.11797/PC1513
    Autors:
    Katihuska ParedesJavier CapillaEmilio MayayoJosep Guarro
    Resum:
    Scopulariopsis is an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation of Scopulariopsis brevicaulis and Scopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed that S. brumptii was more virulent than S. brevicaulis. The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected with S. brumptii, but none showed efficacy against S. brevicaulis. The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy for Scopulariopsis infections remains unresolved.

  • Altres:

    Autor segons l'article: Katihuska Paredes; Javier Capilla; Emilio Mayayo; Josep Guarro
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: PAREDES AGUILAR, KATIHUSKA VIVIANA; CAPILLA LUQUE, JAVIER; MAYAYO ARTAL, EMILIO MANUEL; GUARRO ARTIGAS, JOSEP
    Resum: Scopulariopsis is an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation of Scopulariopsis brevicaulis and Scopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed that S. brumptii was more virulent than S. brevicaulis. The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected with S. brumptii, but none showed efficacy against S. brevicaulis. The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy for Scopulariopsis infections remains unresolved.
    Grup de recerca: Unitat de Micologia i Microbiologia Ambiental
    Àrees temàtiques: Ciències de la salut Ciencias de la salud Health sciences
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0066-4804
    Identificador de l'autor: 0000-0002-0765-6403; 0000-0002-7839-7568
    Data d'alta del registre: 2016-05-04
    Pàgina final: 2068
    Volum de revista: 60
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://aac.asm.org/content/60/4/2063
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1128/AAC.02275-15
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2016
    Pàgina inicial: 2063
    Tipus de publicació: Article Artículo Article

  • Paraules clau:

    Fongs patògens
    Fongs -- Resistència als medicaments
    Agents antifungics
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    0066-4804

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