Articles producció científica> Ciències Mèdiques Bàsiques

Virulence and resistance to antifungal therapies of Scopulariopsis species

  • Datos identificativos

    Identificador: PC:1513
    Autores:
    Katihuska ParedesJavier CapillaEmilio MayayoJosep Guarro
    Resumen:
    Scopulariopsis is an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation of Scopulariopsis brevicaulis and Scopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed that S. brumptii was more virulent than S. brevicaulis. The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected with S. brumptii, but none showed efficacy against S. brevicaulis. The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy for Scopulariopsis infections remains unresolved.
  • Otros:

    Autor según el artículo: Katihuska Paredes; Javier Capilla; Emilio Mayayo; Josep Guarro
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: PAREDES AGUILAR, KATIHUSKA VIVIANA; CAPILLA LUQUE, JAVIER; MAYAYO ARTAL, EMILIO MANUEL; GUARRO ARTIGAS, JOSEP
    Resumen: Scopulariopsis is an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation of Scopulariopsis brevicaulis and Scopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed that S. brumptii was more virulent than S. brevicaulis. The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected with S. brumptii, but none showed efficacy against S. brevicaulis. The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy for Scopulariopsis infections remains unresolved.
    Grupo de investigación: Unitat de Micologia i Microbiologia Ambiental
    Áreas temáticas: Ciències de la salut Ciencias de la salud Health sciences
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0066-4804
    Identificador del autor: 0000-0002-0765-6403; 0000-0002-7839-7568
    Fecha de alta del registro: 2016-05-04
    Página final: 2068
    Volumen de revista: 60
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://aac.asm.org/content/60/4/2063
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1128/AAC.02275-15
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2016
    Página inicial: 2063
    Tipo de publicación: Article Artículo Article
  • Palabras clave:

    Fongs patògens
    Fongs -- Resistència als medicaments
    Agents antifungics
    Ciències de la salut
    Ciencias de la salud
    Health sciences
    0066-4804
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