Autor según el artículo: Katihuska Paredes; Javier Capilla; Emilio Mayayo; Josep Guarro
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: PAREDES AGUILAR, KATIHUSKA VIVIANA; CAPILLA LUQUE, JAVIER; MAYAYO ARTAL, EMILIO MANUEL; GUARRO ARTIGAS, JOSEP
Resumen: Scopulariopsis is an emerging opportunistic fungus characterized by its high resistance to antifungal therapies. We have developed a murine model of disseminated infection in immunosuppressed animals by intravenous inoculation of Scopulariopsis brevicaulis and Scopulariopsis brumptii, the most clinically relevant species, in order to evaluate their virulence and their responses to conventional antifungal treatments. Survival and tissue burden studies showed that S. brumptii was more virulent than S. brevicaulis. The three drugs tested, liposomal amphotericin B, posaconazole, and voriconazole, prolonged the survival of mice infected with S. brumptii, but none showed efficacy against S. brevicaulis. The different therapies were only able to modestly reduce the fungal burden of infected tissue; however, in general, despite the high serum levels reached, they showed poor efficacy in the treatment of the infection. Unfortunately, the most effective therapy for Scopulariopsis infections remains unresolved.
Grupo de investigación: Unitat de Micologia i Microbiologia Ambiental
Áreas temáticas: Ciències de la salut Ciencias de la salud Health sciences
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0066-4804
Identificador del autor: 0000-0002-0765-6403; 0000-0002-7839-7568
Fecha de alta del registro: 2016-05-04
Página final: 2068
Volumen de revista: 60
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Página inicial: 2063
Tipo de publicación: Article Artículo Article
Repositori URV