Autor segons l'article: Jordi Salas-Salvadó; Xiaohui Guo; Anna Tresserra-Rimbau; Ramón Estruch; Miguel A. Martínez-González; Alexander Medina-Remón; Olga Castañer; Dolores Corella; Rosa M. Lamuela-Raventós
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: SALAS SALVADÓ, JORGE; Xiaohui Guo; Anna Tresserra-Rimbau; Ramón Estruch; Miguel A. Martínez-González; Alexander Medina-Remón; Olga Castañer; Dolores Corella; Rosa M. Lamuela-Raventós
Paraules clau: Cholesterol Blood pressure Biomarkers
Resum: Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases. However, accuracy and reliability of these studies may be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay in urine, is correlated with an improvement in cardiovascular risk factors (blood pressure and serum glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, and triglyceride concentrations) in an elderly population at high risk. A longitudinal study was performed with 573 participants (aged 67.3 ± 5.9) from the PREDIMED study (ISRCTN35739639). We used Folin-Ciocalteu method to determine TPE in urine samples, assisting with solid phase extraction. Participants were categorized into three groups according to changes in TPE. Multiple linear regression models were used to assess relationships between TPE and clinical cardiovascular risk factors, adjusting for potential confounders. After a 5-year follow-up, significant inverse correlations were observed between changes in TPE and plasma triglyceride concentration (β = - 8.563; P = 0.007), glucose concentration (β = - 4.164; P = 0.036), and diastolic blood pressure (β = - 1.316; P = 0.013). Our results suggest that the consumption of more polyphenols, measured as TPE in urine, could exert a protective effect against some cardiovascular risk factors.
Grup de recerca: Alimentació, Nutrició, Creixement i Salut Mental
Àrees temàtiques: Biochemistry and technology Bioquímica y tecnología Bioquímica i biotecnologia
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1942-0900
Identificador de l'autor: 0000-0003-2700-7459; n/a; 0000-0002-7022-9041; 0000-0003-1260-4445; n/a; 0000-0003-1985-7592; n/a; 0000-0002-2366-4104; 0000-0002-1287-4560
Data d'alta del registre: 2016-06-10
Volum de revista: 2016
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Pàgina inicial: Article number 2572606
Tipus de publicació: Article Artículo Article
Repositori URV