Articles producció científica> Bioquímica i Biotecnologia

Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population.

  • Dades identificatives

    Identificador: PC:1728
    Autors:
    Jordi Salas-SalvadóDolores CorellaPaula CarrascoMontserrat FitóMiguel Angel Martínez-GonzálezFernando ArósJosé LapetraMarisa GuillénCarolina Ortega-AzorínJulia WarnbergMiquel FiolValentina Ruiz-GutierrezLluís Serra-MajemJ. Alfredo MartínezEmilio RosRamón Estruch
    Resum:
    Genome-wide association studies show that cholesteryl ester transfer protein (CETP) single nucleotide polymorphisms (SNPs) are more strongly associated with HDL cholesterol (HDL-C) concentrations than any other loci across the genome. However, gene-environment interactions for clinical applications are still largely unknown. We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the -4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D'= 0.88; P < 0.001). They were independently associated with higher HDL-C (P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically significant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were found. Likewise, alcohol, dietary fat, and adherence to the Mediterranean diet did not statistically interact with the CETP variants (independently or as diplotype) in determining HDL-C. In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors.
  • Altres:

    Autor segons l'article: Jordi Salas-Salvadó; Dolores Corella; Paula Carrasco; Montserrat Fitó; Miguel Angel Martínez-González; Fernando Arós; José Lapetra; Marisa Guillén; Carolina Ortega-Azorín; Julia Warnberg; Miquel Fiol; Valentina Ruiz-Gutierrez; Lluís Serra-Majem; J. Alfredo Martínez; Emilio Ros; Ramón Estruch
    Departament: Bioquímica i Biotecnologia
    e-ISSN: 1539-7262
    Autor/s de la URV: Salas Salvadó, Jordi
    Paraules clau: lipids nutrigenetics Alcohol
    Resum: Genome-wide association studies show that cholesteryl ester transfer protein (CETP) single nucleotide polymorphisms (SNPs) are more strongly associated with HDL cholesterol (HDL-C) concentrations than any other loci across the genome. However, gene-environment interactions for clinical applications are still largely unknown. We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the -4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D'= 0.88; P < 0.001). They were independently associated with higher HDL-C (P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically significant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were found. Likewise, alcohol, dietary fat, and adherence to the Mediterranean diet did not statistically interact with the CETP variants (independently or as diplotype) in determining HDL-C. In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors.
    Grup de recerca: Alimentació, Nutrició, Creixement i Salut Mental
    Àrees temàtiques: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0022-2275
    Data d'alta del registre: 2016-06-13
    Pàgina final: 2807
    Volum de revista: 51
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.jlr.org/content/early/2010/06/25/jlr.P005199
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1194/jlr.P005199
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2010
    Pàgina inicial: 2798
    Tipus de publicació: Article Artículo Article
  • Paraules clau:

    Nutrició -- Aspectes genètics
    Sistema cardiovascular -- Malalties -- Factors de risc
    Mediterrània, Regió -- Població
    lipids
    nutrigenetics
    Alcohol
    Bioquímica i biotecnologia
    Bioquímica y tecnología
    Biochemistry and technology
    0022-2275
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