Articles producció científica> Bioquímica i Biotecnologia

Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population.

  • Identification data

    Identifier: PC:1728
    Authors:
    Jordi Salas-SalvadóDolores CorellaPaula CarrascoMontserrat FitóMiguel Angel Martínez-GonzálezFernando ArósJosé LapetraMarisa GuillénCarolina Ortega-AzorínJulia WarnbergMiquel FiolValentina Ruiz-GutierrezLluís Serra-MajemJ. Alfredo MartínezEmilio RosRamón Estruch
    Abstract:
    Genome-wide association studies show that cholesteryl ester transfer protein (CETP) single nucleotide polymorphisms (SNPs) are more strongly associated with HDL cholesterol (HDL-C) concentrations than any other loci across the genome. However, gene-environment interactions for clinical applications are still largely unknown. We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the -4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D'= 0.88; P < 0.001). They were independently associated with higher HDL-C (P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically significant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were found. Likewise, alcohol, dietary fat, and adherence to the Mediterranean diet did not statistically interact with the CETP variants (independently or as diplotype) in determining HDL-C. In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors.
  • Others:

    Author, as appears in the article.: Jordi Salas-Salvadó; Dolores Corella; Paula Carrasco; Montserrat Fitó; Miguel Angel Martínez-González; Fernando Arós; José Lapetra; Marisa Guillén; Carolina Ortega-Azorín; Julia Warnberg; Miquel Fiol; Valentina Ruiz-Gutierrez; Lluís Serra-Majem; J. Alfredo Martínez; Emilio Ros; Ramón Estruch
    Department: Bioquímica i Biotecnologia
    e-ISSN: 1539-7262
    URV's Author/s: Salas Salvadó, Jordi
    Keywords: lipids nutrigenetics Alcohol
    Abstract: Genome-wide association studies show that cholesteryl ester transfer protein (CETP) single nucleotide polymorphisms (SNPs) are more strongly associated with HDL cholesterol (HDL-C) concentrations than any other loci across the genome. However, gene-environment interactions for clinical applications are still largely unknown. We studied gene-environment interactions between CETP SNPs and dietary fat intake, adherence to the Mediterranean diet, alcohol consumption, smoking, obesity, and diabetes on HDL-C in 4,210 high cardiovascular risk subjects from a Mediterranean population. We focused on the -4,502C>T and the TaqIB SNPs in partial linkage disequilibrium (D'= 0.88; P < 0.001). They were independently associated with higher HDL-C (P < 0.001); this clinically relevant association was greater when their diplotype was considered (14% higher in TT/B2B2 vs. CC/B1B1). No gene-gene interaction was observed. We also analyzed the association of these SNPs with blood pressure, and no clinically relevant associations were detected. No statistically significant interactions of these SNPs with obesity, diabetes, and smoking in determining HDL-C concentrations were found. Likewise, alcohol, dietary fat, and adherence to the Mediterranean diet did not statistically interact with the CETP variants (independently or as diplotype) in determining HDL-C. In conclusion, the strong association of the CETP SNPs and HDL-C was not statistically modified by diet or by the other environmental factors.
    Research group: Alimentació, Nutrició, Creixement i Salut Mental
    Thematic Areas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0022-2275
    Record's date: 2016-06-13
    Last page: 2807
    Journal volume: 51
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.jlr.org/content/early/2010/06/25/jlr.P005199
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1194/jlr.P005199
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2010
    First page: 2798
    Publication Type: Article Artículo Article
  • Keywords:

    Nutrició -- Aspectes genètics
    Sistema cardiovascular -- Malalties -- Factors de risc
    Mediterrània, Regió -- Població
    lipids
    nutrigenetics
    Alcohol
    Bioquímica i biotecnologia
    Bioquímica y tecnología
    Biochemistry and technology
    0022-2275
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