Autor segons l'article: Ramon A. Alvarez-Puebla; Elena Pazos; Manuel Garcia-Algar; Cristina Penas; Moritz Nazarenus; Arnau Torruella; Nicolas Pazos-Perez; Luca Guerrini; M. Eugenio Vazquez; Eduardo Garcia-Rico; Jose L. Mascareñas
Departament: Química Física i Inorgànica
Autor/s de la URV: ALVAREZ PUEBLA, RAMON ANGEL; Elena Pazos; Manuel Garcia-Algar; Cristina Penas; Moritz Nazarenus; Arnau Torruella; Nicolas Pazos-Perez; Luca Guerrini; M. Eugenio Vazquez; Eduardo Garcia-Rico; Jose L. Mascareñas
Paraules clau: Biopsy Raman scattering Surface enhanced Raman Scattering
Resum: Blood-based biomarkers (liquid biopsy) offer extremely valuable tools for the noninvasive diagnosis and monitoring of tumors. The protein c-MYC, a transcription factor that has been shown to be deregulated in up to 70% of human cancers, can be used as a robust proteomic signature for cancer. Herein, we developed a rapid, highly specific, and sensitive surface-enhanced Raman scattering (SERS) assay for the quantification of c-MYC in real blood samples. The sensing scheme relies on the use of specifically designed hybrid plasmonic materials and their bioderivatization with a selective peptidic receptor modified with a SERS transducer. Peptide/c-MYC recognition events translate into measurable alterations of the SERS spectra associated with a molecular reorientation of the transducer, in agreement with the surface selection rules. The efficiency of the sensor is demonstrated in cellular lines, healthy donors and a cancer patient.
Grup de recerca: Grupo de Plasmonica y Ultradetección
Àrees temàtiques: Química Química Chemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0002-7863
Identificador de l'autor: 0000-0003-4770-5756; 0000-0001-9397-2703; n/a; n/a; n/a; n/a; n/a; 0000-0002-2925-1562; n/a; n/a; 0000-0002-7789-700X
Data d'alta del registre: 2016-11-25
Pàgina final: 14209
Volum de revista: 138
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: http://pubs.acs.org/doi/abs/10.1021/jacs.6b08957
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1021/jacs.6b08957
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Pàgina inicial: 14206
Tipus de publicació: Article Artículo Article
Repositori URV