Autor segons l'article: Mas, A.; González, B.; Beltran, G.; Cullen, P.J.; Torija, M.J.
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: MAS BARON, ALBERTO; González, B.; BELTRAN CASELLAS, GEMMA; Cullen, P.J.; TORIJA MARTÍNEZ, MARÍA JESÚS
Paraules clau: filamentous growth pseudohyphal growth quorum sensing
Resum: In yeast, ethanol is produced as a by-product of fermentation through glycolysis. Ethanol also stimulates a developmental foraging response called filamentous growth and is thought to act as a quorum-sensing molecule. Ethanol-inducible filamentous growth was examined in a small collection of wine/European strains, which validated ethanol as an inducer of filamentous growth. Wine strains also showed variability in their filamentation responses, which illustrates the striking phenotypic differences that can occur among individuals. Ethanol-inducible filamentous growth in 61278b strains was independent of several of the major filamentation regulatory pathways [including fMAPK, RAS-cAMP, Snf1, Rpd3(L), and Rim101] but required the mitochondrial retrograde (RTG) pathway, an inter-organellar signaling pathway that controls the nuclear response to defects in mitochondrial function. The RTG pathway regulated ethanol-dependent filamentous growth by maintaining flux through the TCA cycle. The ethanol-dependent invasive growth response required the polarisome and transcriptional induction of the cell adhesion molecule Flo11p. Our results validate established stimuli that trigger filamentous growth and show how stimuli can trigger highly specific responses among individuals. Our results also connect an inter-organellar pathway to a quorum sensing response in fungi.
Grup de recerca: Biotecnologia Enològica
Àrees temàtiques: Enologia Enología Oenology
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 1664-042X
Identificador de l'autor: 0000-0002-0763-1679; n/a; 0000-0002-7071-205X; n/a; 0000-0001-6419-0745
Data d'alta del registre: 2017-05-18
Volum de revista: 8
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: http://journal.frontiersin.org/article/10.3389/fphys.2017.00148/full
DOI de l'article: 10.3389/fphys.2017.00148
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Pàgina inicial: Art.num. 148
Tipus de publicació: Article Artículo Article
Repositori URV