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Combining cationic and anionic mixed-mode sorbents in a single cartridge to extract basic and acidic pharmaceuticals simultaneously from environmental samples

  • Dades identificatives

    Identificador: PC:3024
    Handle: https://hdl.handle.net/20.500.11797/PC3024
    Autors:
    Borrull, F.Salas, D.Fontanals, N.Marcé, R. M.
    Resum:
    The aim of the present study is to broaden the applications of mixed-mode ion-exchange solid-phase extraction sorbents to extract both basic and acidic compounds simultaneously by combining the sorbents in a single cartridge and developing a simplified extraction procedure. Four different cartridges containing negative and positive charges in the same configuration were evaluated and compared to extract a group of basic, neutral, and acidic pharmaceuticals selected as model compounds. After a thorough optimization of the extraction conditions, the four different cartridges showed to be capable of retaining basic and acidic pharmaceuticals simultaneously through ionic interactions, allowing the introduction of a washing step with 15 mL methanol to eliminate interferences retained by hydrophobic interactions. Using the best combined cartridge, a method was developed, validated, and further applied to environmental waters to demonstrate that the method is promising for the extraction of basic and acidic compounds from very complex samples.

  • Altres:

    Autor segons l'article: Borrull, F. ; Salas, D. ; Fontanals, N. ; Marcé, R. M.
    Departament: Química Analítica i Química Orgànica
    Autor/s de la URV: BORRULL BALLARÍN, FRANCESC; Salas, D. ; Fontanals, N. ; MARCÉ RECASENS, ROSA MARIA
    Paraules clau: Cationic mixed-mode solid-phase extraction Anionicmixed-mode solid-phase extraction High-resolutionmass spectrometry
    Resum: The aim of the present study is to broaden the applications of mixed-mode ion-exchange solid-phase extraction sorbents to extract both basic and acidic compounds simultaneously by combining the sorbents in a single cartridge and developing a simplified extraction procedure. Four different cartridges containing negative and positive charges in the same configuration were evaluated and compared to extract a group of basic, neutral, and acidic pharmaceuticals selected as model compounds. After a thorough optimization of the extraction conditions, the four different cartridges showed to be capable of retaining basic and acidic pharmaceuticals simultaneously through ionic interactions, allowing the introduction of a washing step with 15 mL methanol to eliminate interferences retained by hydrophobic interactions. Using the best combined cartridge, a method was developed, validated, and further applied to environmental waters to demonstrate that the method is promising for the extraction of basic and acidic compounds from very complex samples.
    Grup de recerca: Grup de Cromatografia. Aplicacions Mediambientals
    Àrees temàtiques: Química Química Chemistry
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1618-2642
    Identificador de l'autor: 0000-0003-2718-9336; ; ; 0000-0002-5667-2899
    Data d'alta del registre: 2018-03-01
    Pàgina final: 469
    Volum de revista: 410
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://link.springer.com/article/10.1007/s00216-017-0736-5
    Programa de finançament: plan; Excelencia; CTQ2014-52617-P plan; PhD fellowship; BES-2012-057792
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI de l'article: 10.1007/s00216-017-0736-5
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2018
    Pàgina inicial: 459
    Tipus de publicació: Article Artículo Article

  • Paraules clau:

    Extracció (Química)
    Espectrometria de masses
    Cationic mixed-mode solid-phase extraction
    Anionicmixed-mode solid-phase extraction
    High-resolutionmass spectrometry
    Química
    Química
    Chemistry
    1618-2642

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