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Combining cationic and anionic mixed-mode sorbents in a single cartridge to extract basic and acidic pharmaceuticals simultaneously from environmental samples

  • Identification data

    Identifier: PC:3024
    Handle: https://hdl.handle.net/20.500.11797/PC3024
    Authors:
    Borrull, F.Salas, D.Fontanals, N.Marcé, R. M.
    Abstract:
    The aim of the present study is to broaden the applications of mixed-mode ion-exchange solid-phase extraction sorbents to extract both basic and acidic compounds simultaneously by combining the sorbents in a single cartridge and developing a simplified extraction procedure. Four different cartridges containing negative and positive charges in the same configuration were evaluated and compared to extract a group of basic, neutral, and acidic pharmaceuticals selected as model compounds. After a thorough optimization of the extraction conditions, the four different cartridges showed to be capable of retaining basic and acidic pharmaceuticals simultaneously through ionic interactions, allowing the introduction of a washing step with 15 mL methanol to eliminate interferences retained by hydrophobic interactions. Using the best combined cartridge, a method was developed, validated, and further applied to environmental waters to demonstrate that the method is promising for the extraction of basic and acidic compounds from very complex samples.

  • Others:

    Author, as appears in the article.: Borrull, F. ; Salas, D. ; Fontanals, N. ; Marcé, R. M.
    Department: Química Analítica i Química Orgànica
    URV's Author/s: BORRULL BALLARÍN, FRANCESC; Salas, D. ; Fontanals, N. ; MARCÉ RECASENS, ROSA MARIA
    Keywords: Cationic mixed-mode solid-phase extraction Anionicmixed-mode solid-phase extraction High-resolutionmass spectrometry
    Abstract: The aim of the present study is to broaden the applications of mixed-mode ion-exchange solid-phase extraction sorbents to extract both basic and acidic compounds simultaneously by combining the sorbents in a single cartridge and developing a simplified extraction procedure. Four different cartridges containing negative and positive charges in the same configuration were evaluated and compared to extract a group of basic, neutral, and acidic pharmaceuticals selected as model compounds. After a thorough optimization of the extraction conditions, the four different cartridges showed to be capable of retaining basic and acidic pharmaceuticals simultaneously through ionic interactions, allowing the introduction of a washing step with 15 mL methanol to eliminate interferences retained by hydrophobic interactions. Using the best combined cartridge, a method was developed, validated, and further applied to environmental waters to demonstrate that the method is promising for the extraction of basic and acidic compounds from very complex samples.
    Research group: Grup de Cromatografia. Aplicacions Mediambientals
    Thematic Areas: Química Química Chemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1618-2642
    Author identifier: 0000-0003-2718-9336; ; ; 0000-0002-5667-2899
    Record's date: 2018-03-01
    Last page: 469
    Journal volume: 410
    Papper version: info:eu-repo/semantics/acceptedVersion
    Funding program: plan; Excelencia; CTQ2014-52617-P plan; PhD fellowship; BES-2012-057792
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2018
    First page: 459
    Publication Type: Article Artículo Article

  • Keywords:

    Extracció (Química)
    Espectrometria de masses
    Cationic mixed-mode solid-phase extraction
    Anionicmixed-mode solid-phase extraction
    High-resolutionmass spectrometry
    Química
    Química
    Chemistry
    1618-2642

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