Autor segons l'article: Santafé, M.M. Garcia, N. Tomàs, M. Obis, T. Lanuza M.A. Besalduch N. Tomàs J.
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Manel M. Santafé; Neus Garcia; Marta Tomàs; Teresa Obis; Maria A. Lanuza; Nuria Besalduch; Josep Tomàs
Resum: We conducted an electrophysiological study of the functional link between the tropomyosin-related kinase B (trkB) receptor signaling mechanism and serine-threonine kinases, both protein kinase C (PKC) and protein kinase A (PKA). We describe their coordinated role in transmitter release at the neuromuscular junction (NMJ) of the Levator auris longus muscle of the adult mouse. The trkB receptor normally seems to be coupled to stimulate ACh release because inhibiting the trkB receptor with K-252a results in a significant reduction in the size of EPPs. We found that the intracellular PKC pathway can operate as in basal conditions (to potentiate ACh release) without the involvement of the trkB receptor function, although the trkB pathway needs an operative PKC pathway if it is to couple to the release mechanism and potentiate it. To actively stimulate PKA (which also results in ACh release potentiation), the operativity of trkB is a necessary condition, and one effect of trkB may be PKA stimulation.
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0304-3940
Pàgina final: 175
Volum de revista: 251
Versió de l'article dipositat: info:eu-repo/semantics/submittedVersion
Enllaç font original: http://www.sciencedirect.com/science/article/pii/S030439401400010X
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1016/j.neulet.2013.12.073
Entitat: Universitat Rovira i Virgili.
Any de publicació de la revista: 2014
Pàgina inicial: 171
Repositori URV