Articles producció científica> Ciències Mèdiques Bàsiques

The interaction between tropomyosin-related kinase B receptors and serine kinases modulates acetylcholine release in adult neuromuscular junctions

  • Identification data

    Identifier: PC:973
    Authors:
    Santafé, M.M.Garcia, N.Tomàs, M.Obis, T.Lanuza M.A.Besalduch N.Tomàs J.
    Abstract:
    10.1016/j.neulet.2013.12.073
  • Others:

    Author, as appears in the article.: Santafé, M.M. Garcia, N. Tomàs, M. Obis, T. Lanuza M.A. Besalduch N. Tomàs J.
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Manel M. Santafé; Neus Garcia; Marta Tomàs; Teresa Obis; Maria A. Lanuza; Nuria Besalduch; Josep Tomàs
    Abstract: We conducted an electrophysiological study of the functional link between the tropomyosin-related kinase B (trkB) receptor signaling mechanism and serine-threonine kinases, both protein kinase C (PKC) and protein kinase A (PKA). We describe their coordinated role in transmitter release at the neuromuscular junction (NMJ) of the Levator auris longus muscle of the adult mouse. The trkB receptor normally seems to be coupled to stimulate ACh release because inhibiting the trkB receptor with K-252a results in a significant reduction in the size of EPPs. We found that the intracellular PKC pathway can operate as in basal conditions (to potentiate ACh release) without the involvement of the trkB receptor function, although the trkB pathway needs an operative PKC pathway if it is to couple to the release mechanism and potentiate it. To actively stimulate PKA (which also results in ACh release potentiation), the operativity of trkB is a necessary condition, and one effect of trkB may be PKA stimulation.
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 0304-3940
    Last page: 175
    Journal volume: 251
    Papper version: info:eu-repo/semantics/submittedVersion
    Link to the original source: http://www.sciencedirect.com/science/article/pii/S030439401400010X
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.neulet.2013.12.073
    Entity: Universitat Rovira i Virgili.
    Journal publication year: 2014
    First page: 171