Autor segons l'article: Yu, Edward; Ruiz-Canela, Miguel; Hu, Frank B; Clish, Clary B; Corella, Dolores; Salas-Salvado, Jordi; Hruby, Adela; Fito, Montserrat; Liang, Liming; Toledo, Estefania; Ros, Emilio; Estruch, Ramon; Gomez-Gracia, Enrique; Lapetra, Jose; Aros, Fernando; Romaguera, Dora; Serra-Majem, Lluis; Guasch-Ferre, Marta; Wang, Dong D; Martinez-Gonzalez, Miguel A
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Salas Salvadó, Jorge
Paraules clau: Risk-factors; Randomized-trial; Nitric-oxide synthase; Metabolic syndrome; Mediterranean-style diet; L-arginine intake; Endothelial dysfunction; Coronary-heart-disease; Clinical-trial; Asymmetric dimethylarginine
Resum: Arginine, its methylated metabolites, and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time.To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease (CVD) in a case-cohort setting.A case-cohort study was nested within the Prevención con Dieta Mediterránea trial. We used liquid chromatography-tandem mass spectrometry to assess metabolite levels at baseline and after 1-year follow-up. The primary CVD outcome was a composite of myocardial infarction, stroke and cardiovascular death. We used weighted Cox regression models (Barlow weights) to estimate multivariable-adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs).Multicenter randomized trial in Spain.Participants were 984 participants accruing 231 events over 4.7 years' median follow-up.Incident CVD.Baseline arginine/asymmetric dimethylarginine ratio [HR per standard deviation (SD) = 0.80; 95% CI, 0.67 to 0.96] and global arginine availability [arginine / (ornithine + citrulline)] (HR per SD = 0.83; 95% CI, 0.69 to 1.00) were significantly associated with lower risk of CVD. We observed no significant association for 1-year changes in these ratios or any effect modification by the Mediterranean diet (MD) intervention.A higher baseline arginine/asymmetric dimethylarginine ratio was associated with lower CVD incidence in a high cardiovascular risk population. The intervention with the MD did not change 1-year levels of these metabolites.Copyright © 2017 Endocrine Society
Àrees temàtiques: Sociología; Saúde coletiva; Odontología; Nutrição; Medicine (miscellaneous); Medicina iii; Medicina ii; Medicina i; Interdisciplinar; General medicine; Farmacia; Engenharias ii; Enfermagem; Endocrinology, diabetes and metabolism; Endocrinology & metabolism; Endocrinology; Educação física; Clinical biochemistry; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Biotecnología; Biochemistry (medical); Biochemistry
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0021972X
Adreça de correu electrònic de l'autor: jordi.salas@urv.cat
Data d'alta del registre: 2025-02-17
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://academic.oup.com/jcem/article/102/6/1879/3060512?login=false
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Journal Of Clinical Endocrinology & Metabolism. 102 (6): 1879-1888
Referència de l'ítem segons les normes APA: Yu, Edward; Ruiz-Canela, Miguel; Hu, Frank B; Clish, Clary B; Corella, Dolores; Salas-Salvado, Jordi; Hruby, Adela; Fito, Montserrat; Liang, Liming; T (2017). Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study. Journal Of Clinical Endocrinology & Metabolism, 102(6), 1879-1888. DOI: 10.1210/jc.2016-3569
DOI de l'article: 10.1210/jc.2016-3569
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2017
Tipus de publicació: Journal Publications
Repositori URV