Author, as appears in the article.: Yu, Edward; Ruiz-Canela, Miguel; Hu, Frank B.; Clish, Clary B.; Corella, Dolores; Salas-Salvado, Jordi; Hruby, Adela; Fito, Montserrat; Liang, Liming; Toledo, Estefania; Ros, Emilio; Estruch, Ramon; Gomez-Gracia, Enrique; Lapetra, Jose; Aros, Fernando; Romaguera, Dora; Serra-Majem, Lluis; Guasch-Ferre, Marta; Wang, Dong D.; Martinez-Gonzalez, Miguel A.;
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Risk-factors Randomized-trial Nitric-oxide synthase Metabolic syndrome Mediterranean-style diet L-arginine intake Endothelial dysfunction Coronary-heart-disease Clinical-trial Asymmetric dimethylarginine
Abstract: Arginine, its methylated metabolites, and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time.To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease (CVD) in a case-cohort setting.A case-cohort study was nested within the Prevención con Dieta Mediterránea trial. We used liquid chromatography-tandem mass spectrometry to assess metabolite levels at baseline and after 1-year follow-up. The primary CVD outcome was a composite of myocardial infarction, stroke and cardiovascular death. We used weighted Cox regression models (Barlow weights) to estimate multivariable-adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs).Multicenter randomized trial in Spain.Participants were 984 participants accruing 231 events over 4.7 years' median follow-up.Incident CVD.Baseline arginine/asymmetric dimethylarginine ratio [HR per standard deviation (SD) = 0.80; 95% CI, 0.67 to 0.96] and global arginine availability [arginine / (ornithine + citrulline)] (HR per SD = 0.83; 95% CI, 0.69 to 1.00) were significantly associated with lower risk of CVD. We observed no significant association for 1-year changes in these ratios or any effect modification by the Mediterranean diet (MD) intervention.A higher baseline arginine/asymmetric dimethylarginine ratio was associated with lower CVD incidence in a high cardiovascular risk population. The intervention with the MD did not change 1-year levels of these metabolites.Copyright © 2017 Endocrine Society
Thematic Areas: Sociología Saúde coletiva Odontología Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Endocrinology Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry (medical) Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0021972X
Author's mail: jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://academic.oup.com/jcem/article/102/6/1879/3060512?login=false
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Clinical Endocrinology & Metabolism. 102 (6): 1879-1888
APA: Yu, Edward; Ruiz-Canela, Miguel; Hu, Frank B.; Clish, Clary B.; Corella, Dolores; Salas-Salvado, Jordi; Hruby, Adela; Fito, Montserrat; Liang, Liming; (2017). Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study. Journal Of Clinical Endocrinology & Metabolism, 102(6), 1879-1888. DOI: 10.1210/jc.2016-3569
Article's DOI: 10.1210/jc.2016-3569
Entity: Universitat Rovira i Virgili
Journal publication year: 2017
Publication Type: Journal Publications
Repositori URV