Autor según el artículo: Yu, Edward; Ruiz-Canela, Miguel; Hu, Frank B.; Clish, Clary B.; Corella, Dolores; Salas-Salvado, Jordi; Hruby, Adela; Fito, Montserrat; Liang, Liming; Toledo, Estefania; Ros, Emilio; Estruch, Ramon; Gomez-Gracia, Enrique; Lapetra, Jose; Aros, Fernando; Romaguera, Dora; Serra-Majem, Lluis; Guasch-Ferre, Marta; Wang, Dong D.; Martinez-Gonzalez, Miguel A.;
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Salas Salvadó, Jorge
Palabras clave: Risk-factors Randomized-trial Nitric-oxide synthase Metabolic syndrome Mediterranean-style diet L-arginine intake Endothelial dysfunction Coronary-heart-disease Clinical-trial Asymmetric dimethylarginine
Resumen: Arginine, its methylated metabolites, and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time.To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease (CVD) in a case-cohort setting.A case-cohort study was nested within the Prevención con Dieta Mediterránea trial. We used liquid chromatography-tandem mass spectrometry to assess metabolite levels at baseline and after 1-year follow-up. The primary CVD outcome was a composite of myocardial infarction, stroke and cardiovascular death. We used weighted Cox regression models (Barlow weights) to estimate multivariable-adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs).Multicenter randomized trial in Spain.Participants were 984 participants accruing 231 events over 4.7 years' median follow-up.Incident CVD.Baseline arginine/asymmetric dimethylarginine ratio [HR per standard deviation (SD) = 0.80; 95% CI, 0.67 to 0.96] and global arginine availability [arginine / (ornithine + citrulline)] (HR per SD = 0.83; 95% CI, 0.69 to 1.00) were significantly associated with lower risk of CVD. We observed no significant association for 1-year changes in these ratios or any effect modification by the Mediterranean diet (MD) intervention.A higher baseline arginine/asymmetric dimethylarginine ratio was associated with lower CVD incidence in a high cardiovascular risk population. The intervention with the MD did not change 1-year levels of these metabolites.Copyright © 2017 Endocrine Society
Áreas temáticas: Sociología Saúde coletiva Odontología Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Endocrinology Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry (medical) Biochemistry
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 0021972X
Direcció de correo del autor: jordi.salas@urv.cat
Identificador del autor: 0000-0003-2700-7459
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://academic.oup.com/jcem/article/102/6/1879/3060512?login=false
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Journal Of Clinical Endocrinology & Metabolism. 102 (6): 1879-1888
Referencia de l'ítem segons les normes APA: Yu, Edward; Ruiz-Canela, Miguel; Hu, Frank B.; Clish, Clary B.; Corella, Dolores; Salas-Salvado, Jordi; Hruby, Adela; Fito, Montserrat; Liang, Liming; (2017). Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study. Journal Of Clinical Endocrinology & Metabolism, 102(6), 1879-1888. DOI: 10.1210/jc.2016-3569
DOI del artículo: 10.1210/jc.2016-3569
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Tipo de publicación: Journal Publications
Repositori URV