Codi de projecte: 713679
Paraules clau: Incidence Heart diseases Fatty acids Cell membrane Body mass index
Data d'alta del registre: 2023-02-18
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Referència a l'article segons font original: Arteriosclerosis Thrombosis And Vascular Biology. 39 (4): 819-825
Referència de l'ítem segons les normes APA: Papandreou C, Sala-Vila A, Galié S, Muralidharan J, Estruch R, Fitó M, Razquin C, Corella D, Ros E, Timiraos J, Lapetra J, Serra-Majem L, Carlos S, Ca (2019). Association Between Fatty Acids of Blood Cell Membranes and Incidence of Coronary Heart Disease. Arteriosclerosis Thrombosis And Vascular Biology, 39(4), 819-825. DOI: 10.1161/ATVBAHA.118.312073
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Acrònim: MFP-COFUND
Tipus de publicació: Journal Publications
Autor segons l'article: Papandreou C, Sala-Vila A, Galié S, Muralidharan J, Estruch R, Fitó M, Razquin C, Corella D, Ros E, Timiraos J, Lapetra J, Serra-Majem L, Carlos S, Castañer O, Asensio EM, Salas-Salvadó J, Bulló M
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Bulló Bonet, Mònica / Muralidharan, Jananee / Salas Salvadó, Jorge
Resum: Objective- To examine the associations between baseline levels of fatty acids in blood cell membranes and their 1-year changes with the incidence of coronary heart disease (CHD) in older adults at high cardiovascular disease risk. Approach and Results- This is a case-control study nested in the PREDIMED trial (Prevención con Dieta Mediterránea), with 136 CHD cases and 272 controls (matched on age, sex, body mass index, intervention group, and time of permanence in the study to the time event). We used gas chromatography to measure the proportion of 22 fatty acids in blood cell membranes at baseline and after 1 year. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% CIs. After adjustment for classical CHD risk factors and multiple testing, 1 SD increase in baseline levels of C22:0, C24:0 and the sum of individual very long chain saturated fatty acids was associated with 56% (OR, 0.44 [95% CI, 0.28-0.69]), 59% (OR, 0.41 [95% CI, 0.25-0.65]), and 55% (OR, 0.45 [95% CI, 0.29-0.70]) a decreased odds of developing CHD, respectively. Baseline C20:1n9 was associated with higher odds of CHD (OR, 1.58 [95% CI, 1.25-2.00]). Conclusions- Higher levels of C22:0 and C24:0 were associated with a lower CHD incidence, whereas higher levels of C20:1n9 were associated with a higher risk. This study adds to the growing body of evidence suggesting potential differences in the cardiovascular disease effects of different types of circulating saturated fatty acids.
Àrees temàtiques: Saúde coletiva Peripheral vascular disease Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Hematology General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: jordi.salas@urv.cat monica.bullo@urv.cat
ISSN: 10498834
Identificador de l'autor: 0000-0003-2700-7459 0000-0002-0218-7046
Data de publicació de l'article: 7 Feb 2019
Enllaç font original: https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.312073
Programa de finançament: European Union Horizon 2020
DOI de l'article: 10.1161/ATVBAHA.118.312073
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Acció del programa de finançament: Marie Skłodowska-Curie
Repositori URV