Articles producció científica> Bioquímica i Biotecnologia

Association Between Fatty Acids of Blood Cell Membranes and Incidence of Coronary Heart Disease

  • Dades identificatives

    Identificador: imarina:4224873
  • Autors:

    Papandreou C, Sala-Vila A, Galié S, Muralidharan J, Estruch R, Fitó M, Razquin C, Corella D, Ros E, Timiraos J, Lapetra J, Serra-Majem L, Carlos S, Castañer O, Asensio EM, Salas-Salvadó J, Bulló M
  • Altres:

    Codi de projecte: 713679
    Paraules clau: Incidence Heart diseases Fatty acids Cell membrane Body mass index
    Data d'alta del registre: 2023-02-18
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Referència a l'article segons font original: Arteriosclerosis Thrombosis And Vascular Biology. 39 (4): 819-825
    Referència de l'ítem segons les normes APA: Papandreou C, Sala-Vila A, Galié S, Muralidharan J, Estruch R, Fitó M, Razquin C, Corella D, Ros E, Timiraos J, Lapetra J, Serra-Majem L, Carlos S, Ca (2019). Association Between Fatty Acids of Blood Cell Membranes and Incidence of Coronary Heart Disease. Arteriosclerosis Thrombosis And Vascular Biology, 39(4), 819-825. DOI: 10.1161/ATVBAHA.118.312073
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Acrònim: MFP-COFUND
    Tipus de publicació: Journal Publications
    Autor segons l'article: Papandreou C, Sala-Vila A, Galié S, Muralidharan J, Estruch R, Fitó M, Razquin C, Corella D, Ros E, Timiraos J, Lapetra J, Serra-Majem L, Carlos S, Castañer O, Asensio EM, Salas-Salvadó J, Bulló M
    Departament: Bioquímica i Biotecnologia
    Autor/s de la URV: Bulló Bonet, Mònica / Muralidharan, Jananee / Salas Salvadó, Jorge
    Resum: Objective- To examine the associations between baseline levels of fatty acids in blood cell membranes and their 1-year changes with the incidence of coronary heart disease (CHD) in older adults at high cardiovascular disease risk. Approach and Results- This is a case-control study nested in the PREDIMED trial (Prevención con Dieta Mediterránea), with 136 CHD cases and 272 controls (matched on age, sex, body mass index, intervention group, and time of permanence in the study to the time event). We used gas chromatography to measure the proportion of 22 fatty acids in blood cell membranes at baseline and after 1 year. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% CIs. After adjustment for classical CHD risk factors and multiple testing, 1 SD increase in baseline levels of C22:0, C24:0 and the sum of individual very long chain saturated fatty acids was associated with 56% (OR, 0.44 [95% CI, 0.28-0.69]), 59% (OR, 0.41 [95% CI, 0.25-0.65]), and 55% (OR, 0.45 [95% CI, 0.29-0.70]) a decreased odds of developing CHD, respectively. Baseline C20:1n9 was associated with higher odds of CHD (OR, 1.58 [95% CI, 1.25-2.00]). Conclusions- Higher levels of C22:0 and C24:0 were associated with a lower CHD incidence, whereas higher levels of C20:1n9 were associated with a higher risk. This study adds to the growing body of evidence suggesting potential differences in the cardiovascular disease effects of different types of circulating saturated fatty acids.
    Àrees temàtiques: Saúde coletiva Peripheral vascular disease Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Hematology General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Biodiversidade
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    Adreça de correu electrònic de l'autor: jordi.salas@urv.cat monica.bullo@urv.cat
    ISSN: 10498834
    Identificador de l'autor: 0000-0003-2700-7459 0000-0002-0218-7046
    Data de publicació de l'article: 7 Feb 2019
    Enllaç font original: https://www.ahajournals.org/doi/10.1161/ATVBAHA.118.312073
    Programa de finançament: European Union Horizon 2020
    DOI de l'article: 10.1161/ATVBAHA.118.312073
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2019
    Acció del programa de finançament: Marie Skłodowska-Curie
  • Paraules clau:

    Cardiology and Cardiovascular Medicine,Hematology,Peripheral Vascular Disease
    Incidence
    Heart diseases
    Fatty acids
    Cell membrane
    Body mass index
    Saúde coletiva
    Peripheral vascular disease
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Hematology
    General medicine
    Farmacia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Cardiology and cardiovascular medicine
    Biodiversidade
    10498834
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