Autor segons l'article: Ejarque M, Guerrero-Pérez F, de la Morena N, Casajoana A, Virgili N, López-Urdiales R, Maymó-Masip E, Pujol Gebelli J, Garcia Ruiz de Gordejuela A, Perez-Maraver M, Pellitero S, Fernández-Veledo S, Vendrell J, Vilarrasa N
Departament: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques
Autor/s de la URV: Fernandez Veledo, Sonia / Maymo Masip, Elsa / Vendrell Ortega, Juan José
Paraules clau: Good health and well-being
Resum: We aimed to explore the relationship between GLP-1 receptor (GLP-1R) expression in adipose tissue (AT) and incretin secretion, glucose homeostasis and weight loss, in patients with morbid obesity and type 2 diabetes undergoing bariatric surgery. RNA was extracted from subcutaneous (SAT) and visceral (VAT) AT biopsies from 40 patients randomized to metabolic gastric bypass, sleeve gastrectomy or greater curvature plication. Biochemical parameters, fasting plasma insulin, glucagon and area under the curve (AUC) of GLP-1 following a standard meal test were determined before and 1 year after bariatric surgery. GLP-1R expression was higher in VAT than in SAT. GLP-1R expression in VAT correlated with weight (r = -0.453, p = 0.008), waist circumference (r = -0.494, p = 0.004), plasma insulin (r = -0.466, p = 0.007), and systolic blood pressure (BP) (r = -0.410, p = 0.018). At 1 year, GLP-1R expression in VAT was negatively associated with diastolic BP (r = -0.361, p = 0.039) and, following metabolic gastric bypass, with the increase of GLP-1 AUC, (R2 = 0.46, p = 0.038). Finally, GLP-1R in AT was similar independently of diabetes outcomes and was not associated with weight loss after surgery. Thus, GLP-1R expression in AT is of limited value to predict incretin response and does not play a role in metabolic outcomes after bariatric surgery.
Àrees temàtiques: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Adreça de correu electrònic de l'autor: elsa.maymo@urv.cat sonia.fernandez@urv.cat jvortega@iispv.cat
Identificador de l'autor: 0000-0002-9133-3120 0000-0003-2906-3788 0000-0002-6994-6115
Data d'alta del registre: 2024-11-16
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.nature.com/articles/s41598-019-42770-1
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Scientific Reports. 9 (1): 6274-6274
Referència de l'ítem segons les normes APA: Ejarque M, Guerrero-Pérez F, de la Morena N, Casajoana A, Virgili N, López-Urdiales R, Maymó-Masip E, Pujol Gebelli J, Garcia Ruiz de Gordejuela A, Pe (2019). Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes.. Scientific Reports, 9(1), 6274-6274. DOI: 10.1038/s41598-019-42770-1
DOI de l'article: 10.1038/s41598-019-42770-1
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Tipus de publicació: Journal Publications
Repositori URV