Autor según el artículo: Ejarque, Miriam; Guerrero-Perez, Fernando; de la Morena, Nuria; Casajoana, Anna; Virgili, Nuria; Lopez-Urdiales, Rafael; Maymo-Masip, Elsa; Pujol Gebelli, Jordi; Ruiz de Gordejuela, Amador Garcia; Perez-Maraver, Manuel; Pellitero, Silvia; Fernandez-Veledo, Sonia; Vendrell, Joan; Vilarrasa, Nuria
Departamento: Bioquímica i Biotecnologia; Ciències Mèdiques Bàsiques
Autor/es de la URV: Fernandez Veledo, Sonia / Maymo Masip, Elsa / Vendrell Ortega, Juan José
Palabras clave: Young adult; Weight loss; Stomach; Obesity, morbid; Middle aged; Male; Incretins; Humans; Good health and well-being; Glucagon-like peptide-1 receptor; Glp1r protein, human; Gastric bypass; Gastrectomy; Female; Fasting; Diabetes mellitus, type 2; Blood glucose; Bariatric surgery; Adult; Adolescent; Adipose tissue
Resumen: We aimed to explore the relationship between GLP-1 receptor (GLP-1R) expression in adipose tissue (AT) and incretin secretion, glucose homeostasis and weight loss, in patients with morbid obesity and type 2 diabetes undergoing bariatric surgery. RNA was extracted from subcutaneous (SAT) and visceral (VAT) AT biopsies from 40 patients randomized to metabolic gastric bypass, sleeve gastrectomy or greater curvature plication. Biochemical parameters, fasting plasma insulin, glucagon and area under the curve (AUC) of GLP-1 following a standard meal test were determined before and 1 year after bariatric surgery. GLP-1R expression was higher in VAT than in SAT. GLP-1R expression in VAT correlated with weight (r = -0.453, p = 0.008), waist circumference (r = -0.494, p = 0.004), plasma insulin (r = -0.466, p = 0.007), and systolic blood pressure (BP) (r = -0.410, p = 0.018). At 1 year, GLP-1R expression in VAT was negatively associated with diastolic BP (r = -0.361, p = 0.039) and, following metabolic gastric bypass, with the increase of GLP-1 AUC, (R2 = 0.46, p = 0.038). Finally, GLP-1R in AT was similar independently of diabetes outcomes and was not associated with weight loss after surgery. Thus, GLP-1R expression in AT is of limited value to predict incretin response and does not play a role in metabolic outcomes after bariatric surgery.
Áreas temáticas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Psicología; Odontología; Nutrição; Multidisciplinary sciences; Multidisciplinary; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Letras / linguística; Interdisciplinar; Geografía; Geociências; Farmacia; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Economia; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Ciência da computação; Biotecnología; Biodiversidade; Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20452322
Direcció de correo del autor: elsa.maymo@urv.cat; sonia.fernandez@urv.cat; jvortega@iispv.cat
Fecha de alta del registro: 2025-02-01
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.nature.com/articles/s41598-019-42770-1
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Scientific Reports. 9 (1): 6274-6274
Referencia de l'ítem segons les normes APA: Ejarque, Miriam; Guerrero-Perez, Fernando; de la Morena, Nuria; Casajoana, Anna; Virgili, Nuria; Lopez-Urdiales, Rafael; Maymo-Masip, Elsa; Pujol Gebe (2019). Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes.. Scientific Reports, 9(1), 6274-6274. DOI: 10.1038/s41598-019-42770-1
DOI del artículo: 10.1038/s41598-019-42770-1
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications
Repositori URV