Autor segons l'article: Sanchis, Marta; Javier Pastor, Francisco; Capilla, Javier; Sutton, Deanna A; Fothergill, Annette W; Guarro, Josep
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / PASTOR MOLAS, FRANCISCO JAVIER / Sanchis Talón, Marta
Paraules clau: Voriconazole; Triazoles; Resistance; Posaconazole; Neutropenic murine model; Microbial sensitivity tests; Fluconazole; Efficacy; Disseminated infection; Candida; Azoles; Aspergillosis; Antifungal agents
Resum: We evaluated the in vitro kffling activity of voriconazole (VRC) and posaconazole (PSC) against two clinical isolates of Candida guilliermondii. The two drugs showed fungistatic activity against both isolates and were effective in reducing kidney fungal burden in a neutropenic murine model of disseminated candidiasis in infected mice. PSC was significantly more effective than VRC against one of the strains. The serum levels of PSC and VRC were above the corresponding MICs for these isolates
Àrees temàtiques: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Infectious diseases; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Adreça de correu electrònic de l'autor: marta.sanchis@urv.cat; javier.capilla@urv.cat
Data d'alta del registre: 2025-01-08
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://journals.asm.org/doi/10.1128/aac.03051-14
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Antimicrobial Agents And Chemotherapy. 58 (10): 6255-6257
Referència de l'ítem segons les normes APA: Sanchis, Marta; Javier Pastor, Francisco; Capilla, Javier; Sutton, Deanna A; Fothergill, Annette W; Guarro, Josep (2014). Experimental therapy with azoles against Candida guilliermondii. Antimicrobial Agents And Chemotherapy, 58(10), 6255-6257. DOI: 10.1128/AAC.03051-14
DOI de l'article: 10.1128/AAC.03051-14
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2014
Tipus de publicació: Journal Publications
Repositori URV