Articles producció científica> Ciències Mèdiques Bàsiques

Experimental therapy with azoles against Candida guilliermondii

  • Dades identificatives

    Identificador: imarina:5128221
    Autors:
    Sanchis, M., Pastor, F.J., Capilla, J., Sutton, D.A., Fothergill, A.W., Guarro, J.
    Resum:
    We evaluated the in vitro kffling activity of voriconazole (VRC) and posaconazole (PSC) against two clinical isolates of Candida guilliermondii. The two drugs showed fungistatic activity against both isolates and were effective in reducing kidney fungal burden in a neutropenic murine model of disseminated candidiasis in infected mice. PSC was significantly more effective than VRC against one of the strains. The serum levels of PSC and VRC were above the corresponding MICs for these isolates
  • Altres:

    Autor segons l'article: Sanchis, M., Pastor, F.J., Capilla, J., Sutton, D.A., Fothergill, A.W., Guarro, J.
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / PASTOR MOLAS, FRANCISCO JAVIER / Sanchis Talón, Marta
    Paraules clau: Voriconazole Resistance Posaconazole Neutropenic murine model Fluconazole Efficacy Disseminated infection Aspergillosis
    Resum: We evaluated the in vitro kffling activity of voriconazole (VRC) and posaconazole (PSC) against two clinical isolates of Candida guilliermondii. The two drugs showed fungistatic activity against both isolates and were effective in reducing kidney fungal burden in a neutropenic murine model of disseminated candidiasis in infected mice. PSC was significantly more effective than VRC against one of the strains. The serum levels of PSC and VRC were above the corresponding MICs for these isolates
    Àrees temàtiques: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00664804
    Adreça de correu electrònic de l'autor: marta.sanchis@urv.cat javier.capilla@urv.cat
    Identificador de l'autor: 0000-0001-7251-6792 0000-0002-0765-6403
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://journals.asm.org/doi/10.1128/aac.03051-14
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Antimicrobial Agents And Chemotherapy. 58 (10): 6255-6257
    Referència de l'ítem segons les normes APA: Sanchis, M., Pastor, F.J., Capilla, J., Sutton, D.A., Fothergill, A.W., Guarro, J. (2014). Experimental therapy with azoles against Candida guilliermondii. Antimicrobial Agents And Chemotherapy, 58(10), 6255-6257. DOI: 10.1128/AAC.03051-14
    DOI de l'article: 10.1128/AAC.03051-14
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2014
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Infectious Diseases,Microbiology,Pharmacology,Pharmacology & Pharmacy,Pharmacology (Medical)
    Voriconazole
    Resistance
    Posaconazole
    Neutropenic murine model
    Fluconazole
    Efficacy
    Disseminated infection
    Aspergillosis
    Saúde coletiva
    Química
    Pharmacology (medical)
    Pharmacology & pharmacy
    Pharmacology
    Odontología
    Nutrição
    Microbiology
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Infectious diseases
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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