Author, as appears in the article.: Sanchis, M., Pastor, F.J., Capilla, J., Sutton, D.A., Fothergill, A.W., Guarro, J.
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep / PASTOR MOLAS, FRANCISCO JAVIER / Sanchis Talón, Marta
Keywords: Voriconazole Resistance Posaconazole Neutropenic murine model Fluconazole Efficacy Disseminated infection Aspergillosis
Abstract: We evaluated the in vitro kffling activity of voriconazole (VRC) and posaconazole (PSC) against two clinical isolates of Candida guilliermondii. The two drugs showed fungistatic activity against both isolates and were effective in reducing kidney fungal burden in a neutropenic murine model of disseminated candidiasis in infected mice. PSC was significantly more effective than VRC against one of the strains. The serum levels of PSC and VRC were above the corresponding MICs for these isolates
Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Author's mail: marta.sanchis@urv.cat javier.capilla@urv.cat
Author identifier: 0000-0001-7251-6792 0000-0002-0765-6403
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://journals.asm.org/doi/10.1128/aac.03051-14
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Antimicrobial Agents And Chemotherapy. 58 (10): 6255-6257
APA: Sanchis, M., Pastor, F.J., Capilla, J., Sutton, D.A., Fothergill, A.W., Guarro, J. (2014). Experimental therapy with azoles against Candida guilliermondii. Antimicrobial Agents And Chemotherapy, 58(10), 6255-6257. DOI: 10.1128/AAC.03051-14
Article's DOI: 10.1128/AAC.03051-14
Entity: Universitat Rovira i Virgili
Journal publication year: 2014
Publication Type: Journal Publications
Repositori URV