Articles producció científicaCiències Mèdiques Bàsiques

Experimental therapy with azoles against Candida guilliermondii

  • Identification data

    Identifier:  imarina:5128221
    Handle: https://hdl.handle.net/20.500.11797/imarina5128221
    Authors:  Sanchis, M; Pastor, FJ; Capilla, J; Sutton, DA; Fothergill, AW; Guarro, J
    Abstract:
    We evaluated the in vitro kffling activity of voriconazole (VRC) and posaconazole (PSC) against two clinical isolates of Candida guilliermondii. The two drugs showed fungistatic activity against both isolates and were effective in reducing kidney fungal burden in a neutropenic murine model of disseminated candidiasis in infected mice. PSC was significantly more effective than VRC against one of the strains. The serum levels of PSC and VRC were above the corresponding MICs for these isolates

  • Others:

    Link to the original source: https://journals.asm.org/doi/10.1128/aac.03051-14
    APA: Sanchis, M; Pastor, FJ; Capilla, J; Sutton, DA; Fothergill, AW; Guarro, J (2014). Experimental therapy with azoles against Candida guilliermondii. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(10), 6255-6257. DOI: 10.1128/AAC.03051-14
    Paper original source: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 58 (10): 6255-6257
    Article's DOI: 10.1128/AAC.03051-14
    Journal publication year: 2014-10-01
    Entity: Universitat Rovira i Virgili
    Paper version: info:eu-repo/semantics/publishedVersion
    Record's date: 2026-05-09
    URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep / PASTOR MOLAS, FRANCISCO JAVIER / Sanchis Talón, Marta
    Department: Ciències Mèdiques Bàsiques
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Publication Type: Journal Publications
    ISSN: 00664804
    Author, as appears in the article.: Sanchis, M; Pastor, FJ; Capilla, J; Sutton, DA; Fothergill, AW; Guarro, J
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Thematic Areas: Pharmacology (medical), Pharmacology & pharmacy, Pharmacology, Microbiology, Infectious diseases, Biotecnología, Biodiversidade, Administração pública e de empresas, ciências contábeis e turismo
    Author's mail: marta.sanchis@urv.cat, marta.sanchis@urv.cat, javier.capilla@urv.cat, javier.capilla@urv.cat

  • Keywords:

    Voriconazole
    Triazoles
    Resistance
    Posaconazole
    Neutropenic murine model
    Microbial sensitivity tests
    Good health and well-being
    Fluconazole
    Efficacy
    Disseminated infection
    Candida
    Azoles
    Aspergillosis
    Antifungal agents
    Infectious Diseases
    Microbiology
    Pharmacology
    Pharmacology & Pharmacy
    Pharmacology (Medical)
    Biotecnología
    Biodiversidade
    Administração pública e de empresas
    ciências contábeis e turismo

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