Autor según el artículo: Sanchis, M., Pastor, F.J., Capilla, J., Sutton, D.A., Fothergill, A.W., Guarro, J.
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / PASTOR MOLAS, FRANCISCO JAVIER / Sanchis Talón, Marta
Palabras clave: Voriconazole Resistance Posaconazole Neutropenic murine model Fluconazole Efficacy Disseminated infection Aspergillosis
Resumen: We evaluated the in vitro kffling activity of voriconazole (VRC) and posaconazole (PSC) against two clinical isolates of Candida guilliermondii. The two drugs showed fungistatic activity against both isolates and were effective in reducing kidney fungal burden in a neutropenic murine model of disseminated candidiasis in infected mice. PSC was significantly more effective than VRC against one of the strains. The serum levels of PSC and VRC were above the corresponding MICs for these isolates
Áreas temáticas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Direcció de correo del autor: marta.sanchis@urv.cat javier.capilla@urv.cat
Identificador del autor: 0000-0001-7251-6792 0000-0002-0765-6403
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://journals.asm.org/doi/10.1128/aac.03051-14
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Antimicrobial Agents And Chemotherapy. 58 (10): 6255-6257
Referencia de l'ítem segons les normes APA: Sanchis, M., Pastor, F.J., Capilla, J., Sutton, D.A., Fothergill, A.W., Guarro, J. (2014). Experimental therapy with azoles against Candida guilliermondii. Antimicrobial Agents And Chemotherapy, 58(10), 6255-6257. DOI: 10.1128/AAC.03051-14
DOI del artículo: 10.1128/AAC.03051-14
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2014
Tipo de publicación: Journal Publications
Repositori URV