Autor segons l'article: Mora-Cubillos, Ximena; Tulipani, Sara; Garcia-Aloy, Mar; Bullo, Monica; Tinahones, Francisco J; Andres-Lacueva, Cristina
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Bulló Bonet, Mònica
Paraules clau: Prevention Plasma human Metabolomics Medium-chain Mediterranean diet Intervention Health Gut microbiota Ellagic acid Dicarboxylic-acids Consumption Cardiovascular-disease Biomarkers of nuts Adiposity metabolomics gut microbiota biomarkers of nuts adiposity
Resum: To identify the most discriminant dietary biomarkers of nuts exposure in subjects with metabolic syndrome (MetS), and investigate the potential association between exposure and the severity of the MetS diagnostic traits.We applied the untargeted LC-ESI-qToF-MS-driven metabolomic workflow to explore the changes occurring in the plasma metabolome of MetS subjects following 12-wk intake of mixed nuts (30 g/d; nuts versus control groups). Urolithin A glucuronide was the most discriminative biomarker of nuts exposure, showing the highest predictive capacity (area under the ROC curve = 89.6% [80.8-98.4]) despite the interindividual variation expected for a host-microbial cometabolite. Furthermore, the detection of urolithin A glucuronide in plasma showed significant inverse correlation with basal abdominal adiposity (waist circumference: r = -0.550, p < 0.01; waist-hip ratio: r = -0.409, p < 0.05) and impaired glycemic control (fasting insulin: r = -0.414, p < 0.05; HOMA-IR: r = -0.417, p < 0.05). Significant changes in medium-chain dicarboxylic acids, recognized as alternative energy substrates that are particularly relevant in the case of glycemic control impairment, were also associated with nut consumption.Higher levels of utolithin A glucuronide are reported in subjects with less severe MetS traits, especially in females. We believe that this inverse correlation may be related with profile of gut microbial dysbiosis, recently associated to subjects with MetS.© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Àrees temàtiques: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
Adreça de correu electrònic de l'autor: monica.bullo@urv.cat
Identificador de l'autor: 0000-0002-0218-7046
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201500549
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Molecular Nutrition & Food Research. 59 (12): 2480-2490
Referència de l'ítem segons les normes APA: Mora-Cubillos, Ximena; Tulipani, Sara; Garcia-Aloy, Mar; Bullo, Monica; Tinahones, Francisco J; Andres-Lacueva, Cristina (2015). Plasma metabolomic biomarkers of mixed nuts exposure inversely correlate with severity of metabolic syndrome. Molecular Nutrition & Food Research, 59(12), 2480-2490. DOI: 10.1002/mnfr.201500549
DOI de l'article: 10.1002/mnfr.201500549
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2015
Tipus de publicació: Journal Publications