Autor segons l'article: Thomson, Pamela; Guarro, Josep; Mayayo, Emilio; Capilla, Javier
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel
Paraules clau: Triazoles; Proteoglycans; Posaconazole; Polysaccharide-k; Neutropenia; Mycoses; Microbial sensitivity tests; Mice, inbred strains; Male; Kidney; Immunocompromised host; Good health and well-being; Dose-response relationship, drug; Disease models, animal; Brain; Beta-glucans; Basidiomycota; Antifungal agents; Animals
Resum: The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day (BID) in a murine neutropenic model of systemic infection with S. capitata by testing a set of six clinical isolates. Posaconazole showed fungistatic activity against all of the isolates tested. The different doses of the drug, especially the highest one, showed good efficacy, measured by prolonged survival, reduction of (1-3)-β-D-glucan levels in serum, tissue burden reduction, and histopathology.
Àrees temàtiques: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Infectious diseases; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Adreça de correu electrònic de l'autor: javier.capilla@urv.cat
Data d'alta del registre: 2025-02-18
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://aac.asm.org/content/59/12/7477
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Antimicrobial Agents And Chemotherapy. 59 (12): 7477-7482
Referència de l'ítem segons les normes APA: Thomson, Pamela; Guarro, Josep; Mayayo, Emilio; Capilla, Javier (2015). Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata. Antimicrobial Agents And Chemotherapy, 59(12), 7477-7482. DOI: 10.1128/AAC.01140-15
DOI de l'article: 10.1128/AAC.01140-15
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2015
Tipus de publicació: Journal Publications
Repositori URV