Author, as appears in the article.: Thomson P; Guarro J; Mayayo E; Capilla J

Department: Ciències Mèdiques Bàsiques

URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel

Abstract: The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day (BID) in a murine neutropenic model of systemic infection with S. capitata by testing a set of six clinical isolates. Posaconazole showed fungistatic activity against all of the isolates tested. The different doses of the drug, especially the highest one, showed good efficacy, measured by prolonged survival, reduction of (1-3)-β-D-glucan levels in serum, tissue burden reduction, and histopathology.

Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00664804

Author's mail: josep.guarro@urv.cat emilio.mayayo@urv.cat javier.capilla@urv.cat

Author identifier: 0000-0002-7839-7568 0000-0003-4485-3809 0000-0002-0765-6403

Record's date: 2023-02-18

Papper version: info:eu-repo/semantics/acceptedVersion

Link to the original source: https://aac.asm.org/content/59/12/7477

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Antimicrobial Agents And Chemotherapy. 59 (12): 7477-7482

APA: Thomson P; Guarro J; Mayayo E; Capilla J (2015). Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata. Antimicrobial Agents And Chemotherapy, 59(12), 7477-7482. DOI: 10.1128/AAC.01140-15

Article's DOI: 10.1128/AAC.01140-15

Entity: Universitat Rovira i Virgili

Journal publication year: 2015

Publication Type: Journal Publications