Author, as appears in the article.: Thomson, Pamela; Guarro, Josep; Mayayo, Emilio; Capilla, Javier
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel
Keywords: Triazoles Proteoglycans Posaconazole Polysaccharide-k Neutropenia Mycoses Microbial sensitivity tests Mice, inbred strains Male Kidney Immunocompromised host Good health and well-being Dose-response relationship, drug Disease models, animal Brain Beta-glucans Basidiomycota Antifungal agents Animals
Abstract: The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day (BID) in a murine neutropenic model of systemic infection with S. capitata by testing a set of six clinical isolates. Posaconazole showed fungistatic activity against all of the isolates tested. The different doses of the drug, especially the highest one, showed good efficacy, measured by prolonged survival, reduction of (1-3)-β-D-glucan levels in serum, tissue burden reduction, and histopathology.
Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Author's mail: javier.capilla@urv.cat
Author identifier: 0000-0002-0765-6403
Record's date: 2025-02-18
Paper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Antimicrobial Agents And Chemotherapy. 59 (12): 7477-7482
APA: Thomson, Pamela; Guarro, Josep; Mayayo, Emilio; Capilla, Javier (2015). Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata. Antimicrobial Agents And Chemotherapy, 59(12), 7477-7482. DOI: 10.1128/AAC.01140-15
Entity: Universitat Rovira i Virgili
Journal publication year: 2015
Publication Type: Journal Publications
Repositori URV