Autor según el artículo: Thomson, Pamela; Guarro, Josep; Mayayo, Emilio; Capilla, Javier
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel
Palabras clave: Triazoles; Proteoglycans; Posaconazole; Polysaccharide-k; Neutropenia; Mycoses; Microbial sensitivity tests; Mice, inbred strains; Male; Kidney; Immunocompromised host; Good health and well-being; Dose-response relationship, drug; Disease models, animal; Brain; Beta-glucans; Basidiomycota; Antifungal agents; Animals
Resumen: The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day (BID) in a murine neutropenic model of systemic infection with S. capitata by testing a set of six clinical isolates. Posaconazole showed fungistatic activity against all of the isolates tested. The different doses of the drug, especially the highest one, showed good efficacy, measured by prolonged survival, reduction of (1-3)-β-D-glucan levels in serum, tissue burden reduction, and histopathology.
Áreas temáticas: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Infectious diseases; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Direcció de correo del autor: javier.capilla@urv.cat
Fecha de alta del registro: 2025-02-18
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://aac.asm.org/content/59/12/7477
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Antimicrobial Agents And Chemotherapy. 59 (12): 7477-7482
Referencia de l'ítem segons les normes APA: Thomson, Pamela; Guarro, Josep; Mayayo, Emilio; Capilla, Javier (2015). Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata. Antimicrobial Agents And Chemotherapy, 59(12), 7477-7482. DOI: 10.1128/AAC.01140-15
DOI del artículo: 10.1128/AAC.01140-15
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2015
Tipo de publicación: Journal Publications
Repositori URV