Autor según el artículo: Thomson P; Guarro J; Mayayo E; Capilla J

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / Mayayo Artal, Emilio Manuel

Resumen: The fungus Saprochaete capitata causes opportunistic human infections, mainly in immunocompromised patients with hematological malignancies. The best therapy for this severe infection is still unknown. We evaluated the in vitro killing activity and the in vivo efficacy of posaconazole at 5, 10, or 20 mg/kg twice a day (BID) in a murine neutropenic model of systemic infection with S. capitata by testing a set of six clinical isolates. Posaconazole showed fungistatic activity against all of the isolates tested. The different doses of the drug, especially the highest one, showed good efficacy, measured by prolonged survival, reduction of (1-3)-β-D-glucan levels in serum, tissue burden reduction, and histopathology.

Áreas temáticas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00664804

Direcció de correo del autor: josep.guarro@urv.cat emilio.mayayo@urv.cat javier.capilla@urv.cat

Identificador del autor: 0000-0002-7839-7568 0000-0003-4485-3809 0000-0002-0765-6403

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://aac.asm.org/content/59/12/7477

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Antimicrobial Agents And Chemotherapy. 59 (12): 7477-7482

Referencia de l'ítem segons les normes APA: Thomson P; Guarro J; Mayayo E; Capilla J (2015). Efficacy of Posaconazole in a Murine Model of Systemic Infection by Saprochaete capitata. Antimicrobial Agents And Chemotherapy, 59(12), 7477-7482. DOI: 10.1128/AAC.01140-15

DOI del artículo: 10.1128/AAC.01140-15

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2015

Tipo de publicación: Journal Publications