Topological Defects in Hyperbranched Glycopolymers Enhance Binding to Lectins

Identificador:  imarina:5131923

Handle: https://hdl.handle.net/20.500.11797/imarina5131923

Autors:  Salvadó, M; Reina, JJ; Rojo, J; Castillón, S; Boutureira, O

Resum:
Central scaffold topology and carbohydrate density are important features in determining both the binding mechanism and potency of synthetic multivalent, polydisperse vs. monodisperse carbohydrate systems to a model plant toxin (RCA120). We found lower densities of protein receptors favour the use of heterogeneous, polydisperse glycoconjugate presentations as determined by surface plasmon resonance (SPR) and dynamic light scattering (DLS).