Articles producció científica> Ciències Mèdiques Bàsiques

Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice.

  • Dades identificatives

    Identificador: imarina:5132637
    Autors:
    Antonelli F, Casciati A, Tanori M, Tanno B, Linares-Vidal MV, Serra N, Bellés M, Pannicelli A, Saran A, Pazzaglia S.
    Resum:
    Many genes controlling neuronal development also regulate adult neurogenesis. We investigated in vivo the effect of Sonic hedgehog (Shh) signaling activation on patterning and neurogenesis of the hippocampus and behavior of Patched1 (Ptch1) heterozygous mice (Ptch1+/−). We demonstrated for the first time, that Ptch1+/− mice exhibit morphological, cellular and molecular alterations in the dentate gyrus (DG), including elongation and reduced width of the DG as well as deregulations at multiple steps during lineage progression from neural stem cells to neurons. By using stage-specific cellular markers, we detected reduction of quiescent stem cells, newborn neurons and astrocytes and accumulation of proliferating intermediate progenitors, indicative of defects in the dynamic transition among neural stages. Phenotypic alterations in Ptch1+/− mice were accompanied by expression changes in Notch pathway downstream components and TLX nuclear receptor, as well as perturbations in inflammatory and synaptic networks and mouse behavior, pointing to complex biological interactions and highlighting cooperation between Shh and Notch signaling in the regulation of neurogenesis.
  • Altres:

    Autor segons l'article: Antonelli F, Casciati A, Tanori M, Tanno B, Linares-Vidal MV, Serra N, Bellés M, Pannicelli A, Saran A, Pazzaglia S.
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Bellés Mateu, Montserrat / Linares Vidal, M. Victoria
    Paraules clau: Tlx nuclear receptor Sonic hedgehog pathway Notch pathway Neurogenesis Hippocampal neurogenesis and neuronal lineage differentiation Heterozygous mice Expression profiles of neurogenesis-related genes Dentate gyrus Behavioral effects tlx nuclear receptor notch pathway hippocampal neurogenesis and neuronal lineage differentiation expression profiles of neurogenesis-related genes behavioral effects
    Resum: Many genes controlling neuronal development also regulate adult neurogenesis. We investigated in vivo the effect of Sonic hedgehog (Shh) signaling activation on patterning and neurogenesis of the hippocampus and behavior of Patched1 (Ptch1) heterozygous mice (Ptch1+/−). We demonstrated for the first time, that Ptch1+/− mice exhibit morphological, cellular and molecular alterations in the dentate gyrus (DG), including elongation and reduced width of the DG as well as deregulations at multiple steps during lineage progression from neural stem cells to neurons. By using stage-specific cellular markers, we detected reduction of quiescent stem cells, newborn neurons and astrocytes and accumulation of proliferating intermediate progenitors, indicative of defects in the dynamic transition among neural stages. Phenotypic alterations in Ptch1+/− mice were accompanied by expression changes in Notch pathway downstream components and TLX nuclear receptor, as well as perturbations in inflammatory and synaptic networks and mouse behavior, pointing to complex biological interactions and highlighting cooperation between Shh and Notch signaling in the regulation of neurogenesis.
    Àrees temàtiques: Neurosciences Molecular biology Medicina ii Ciências biológicas ii Cellular and molecular neuroscience
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16625099
    Adreça de correu electrònic de l'autor: mvictoria.linares@urv.cat montserrat.belles@urv.cat
    Identificador de l'autor: 0000-0003-4170-4197 0000-0002-9282-2989
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://www.frontiersin.org/articles/10.3389/fnmol.2018.00168/full
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Frontiers In Molecular Neuroscience. 11 (168): 168-
    Referència de l'ítem segons les normes APA: Antonelli F, Casciati A, Tanori M, Tanno B, Linares-Vidal MV, Serra N, Bellés M, Pannicelli A, Saran A, Pazzaglia S. (2018). Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice.. Frontiers In Molecular Neuroscience, 11(168), 168-. DOI: 10.3389/fnmol.2018.00168
    DOI de l'article: 10.3389/fnmol.2018.00168
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2018
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Cellular and Molecular Neuroscience,Molecular Biology,Neurosciences
    Tlx nuclear receptor
    Sonic hedgehog pathway
    Notch pathway
    Neurogenesis
    Hippocampal neurogenesis and neuronal lineage differentiation
    Heterozygous mice
    Expression profiles of neurogenesis-related genes
    Dentate gyrus
    Behavioral effects
    tlx nuclear receptor
    notch pathway
    hippocampal neurogenesis and neuronal lineage differentiation
    expression profiles of neurogenesis-related genes
    behavioral effects
    Neurosciences
    Molecular biology
    Medicina ii
    Ciências biológicas ii
    Cellular and molecular neuroscience
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