Autor según el artículo: Antonelli F, Casciati A, Tanori M, Tanno B, Linares-Vidal MV, Serra N, Bellés M, Pannicelli A, Saran A, Pazzaglia S.
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Bellés Mateu, Montserrat / Linares Vidal, M. Victoria
Palabras clave: Tlx nuclear receptor Sonic hedgehog pathway Notch pathway Neurogenesis Hippocampal neurogenesis and neuronal lineage differentiation Heterozygous mice Expression profiles of neurogenesis-related genes Dentate gyrus Behavioral effects tlx nuclear receptor notch pathway hippocampal neurogenesis and neuronal lineage differentiation expression profiles of neurogenesis-related genes behavioral effects
Resumen: Many genes controlling neuronal development also regulate adult neurogenesis. We investigated in vivo the effect of Sonic hedgehog (Shh) signaling activation on patterning and neurogenesis of the hippocampus and behavior of Patched1 (Ptch1) heterozygous mice (Ptch1+/−). We demonstrated for the first time, that Ptch1+/− mice exhibit morphological, cellular and molecular alterations in the dentate gyrus (DG), including elongation and reduced width of the DG as well as deregulations at multiple steps during lineage progression from neural stem cells to neurons. By using stage-specific cellular markers, we detected reduction of quiescent stem cells, newborn neurons and astrocytes and accumulation of proliferating intermediate progenitors, indicative of defects in the dynamic transition among neural stages. Phenotypic alterations in Ptch1+/− mice were accompanied by expression changes in Notch pathway downstream components and TLX nuclear receptor, as well as perturbations in inflammatory and synaptic networks and mouse behavior, pointing to complex biological interactions and highlighting cooperation between Shh and Notch signaling in the regulation of neurogenesis.
Áreas temáticas: Neurosciences Molecular biology Medicina ii Ciências biológicas ii Cellular and molecular neuroscience
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16625099
Direcció de correo del autor: mvictoria.linares@urv.cat montserrat.belles@urv.cat
Identificador del autor: 0000-0003-4170-4197 0000-0002-9282-2989
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fnmol.2018.00168/full
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Frontiers In Molecular Neuroscience. 11 (168): 168-
Referencia de l'ítem segons les normes APA: Antonelli F, Casciati A, Tanori M, Tanno B, Linares-Vidal MV, Serra N, Bellés M, Pannicelli A, Saran A, Pazzaglia S. (2018). Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice.. Frontiers In Molecular Neuroscience, 11(168), 168-. DOI: 10.3389/fnmol.2018.00168
DOI del artículo: 10.3389/fnmol.2018.00168
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Tipo de publicación: Journal Publications