Autor segons l'article: Miró-Abella E, Torrell H, Herrero P, Canela N, Arola L, Borrull F, Ras R, Fontanals N.
Departament: Química Analítica i Química Orgànica
Autor/s de la URV: Arola Ferrer, Luis Maria / Fontanals Torroja, Núria / HERRERO GIL, POL
Paraules clau: Uhplc-(esi)ms/ms Rats Mycotoxins Microbiota Metagenomics Faeces rats mycotoxins microbiota metagenomics faeces
Resum: Published evidence has demonstrated the several toxic characteristics of mycotoxins and their considerable risk to human and animal health. One of the most common uncertainties regards whether if very low concentrations of the mycotoxin deoxynivalenol (DON), easily consumed within the Mediterranean Diet, can cause metabolic alterations; some of them produced by the interaction between DON and gut microbiota. Accordingly, faecal samples were collected from Wistar rats that had consumed the mycotoxin DON at low levels (60 and 120 μg kg-1 body weight of DON per day), and were analysed by ultra-high performance liquid chromatography coupled with tandem mass spectrometry detection, in order to monitor the mycotoxin DON and its metabolite de-epoxy deoxynivalenol (DOM-1). The obtained results showed an evolution in DON excretion and the metabolite DOM-1 which has less toxic properties, over the course of the days of the study. To elucidate whether intestinal microbiota had a role in the observed detoxification process, the changes in microbial gut biodiversity were explored through 16s rRNA high throughput sequencing. No main changes were detected but significant increase in Coprococcus genus relative abundance was found. Further studies are needed to confirm if intestinal microbiota composition and function are affected by low mycotoxin concentrations.
Àrees temàtiques: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
ISSN: 02786915
Adreça de correu electrònic de l'autor: nuria.fontanals@urv.cat lluis.arola@urv.cat nuria.fontanals@urv.cat
Identificador de l'autor: 0000-0002-7534-1964 0000-0003-2767-1974 0000-0002-7534-1964
Pàgina final: 130
Data d'alta del registre: 2023-02-18
Volum de revista: 121
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0278691518305179
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Food And Chemical Toxicology. 121 124-130
Referència de l'ítem segons les normes APA: Miró-Abella E, Torrell H, Herrero P, Canela N, Arola L, Borrull F, Ras R, Fontanals N. (2018). Monitoring and evaluation of the interaction between deoxynivalenol and gut microbiota in Wistar rats by mass spectrometry-based metabolomics and next-generation sequencing. Food And Chemical Toxicology, 121(), 124-130. DOI: 10.1016/j.fct.2018.08.006
DOI de l'article: 10.1016/j.fct.2018.08.006
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Pàgina inicial: 124
Tipus de publicació: Journal Publications
Repositori URV