Autor segons l'article: Schreiber E, Alfageme O, Garcia T, González N, Sirvent JJ, Torrente M, Gómez M, Domingo JL
Departament: Bioquímica i Biotecnologia Psicologia Ciències Mèdiques Bàsiques
Autor/s de la URV: Domingo Roig, José Luis / Garcia Soldevila, Tània / Gómez Arnaiz, María Mercedes / Gonzalez Paradell, Nieves / Torrente Torné, Margarita
Paraules clau: Sperm Reproductive toxicity Maternal exposure Endocrine disruptors Dienestrol reproductive toxicity maternal exposure endocrine disruptors dienestrol
Resum: This study was aimed at determining whether dienestrol (DIES) affects reproduction in male offspring of rats following oral maternal exposure during gestation and lactation. Pregnant rats were treated from GD 6 to PND 21. Animals received 0 (control-vehicle), 0.75, 1.5, 3.12, 6.25, 12.5, 50, 75 μg/kg bw/d of DIES. A control group -without vehicle-was also included. High DIES concentrations caused abortions at 75 and 50 μg/kg bw/d, while at 12.5 μg/kg bw/d had still miscarriages. Ten male rats per group were kept alive until PND 90 to ensure sexual maturity. Body and organ weights, anogenital distance (AGD) at PNDs 21 and 90, biochemical and sperm parameters like motility, viability, morphology, spermatozoa and resistant spermatid counts, and histopathology for sexual organs and liver were determined. An increase in organ weight (liver and sexual organs) and a decrease in AGD due to vehicle were found. A reduction of sperm motility and viability, and an increase of abnormal sperm morphology were caused by DIES, which provoked a dose-dependent prostatitis. Maternal exposure to DIES induced toxicity on the reproductive system of the male offspring, which could affect the capacity of fertilization.
Àrees temàtiques: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Adreça de correu electrònic de l'autor: nieves.gonzalez@urv.cat margarita.torrente@urv.cat joseluis.domingo@urv.cat
Identificador de l'autor: 0000-0003-4134-016X 0000-0002-8901-6345 0000-0001-6647-9470
Pàgina final: 201
Data d'alta del registre: 2024-06-28
Volum de revista: 128
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/pii/S0278691519302121?via%3Dihub
Referència a l'article segons font original: Food And Chemical Toxicology. 128 193-201
Referència de l'ítem segons les normes APA: Schreiber E, Alfageme O, Garcia T, González N, Sirvent JJ, Torrente M, Gómez M, Domingo JL (2019). Oral exposure of rats to dienestrol during gestation and lactation: Effects on the reproductive system of male offspring. Food And Chemical Toxicology, 128(), 193-201. DOI: 10.1016/j.fct.2019.04.013
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1016/j.fct.2019.04.013
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Pàgina inicial: 193
Tipus de publicació: Journal Publications
Repositori URV