Author, as appears in the article.: Schreiber, Elga; Alfageme, Oscar; Garcia, Tania; Gonzalez, Neus; Jose Sirvent, Juan; Torrente, Margarita; Gomez, Mercedes; Domingo, Jose L
Department: Bioquímica i Biotecnologia Psicologia Ciències Mèdiques Bàsiques
URV's Author/s: Domingo Roig, José Luis / Garcia Soldevila, Tània / Gómez Arnaiz, María Mercedes / Gonzalez Paradell, Nieves / Torrente Torné, Margarita
Keywords: Spermatozoa Sperm motility Sperm count Sperm Reproductive toxicity Rats Prostatitis Pregnancy Organ size Maternal exposure Male Genitalia, male Female Estrogens, non-steroidal Endocrine disruptors Dose-response relationship, drug Dienestrol Body weight Animals Administration, oral Abortion, veterinary reproductive toxicity maternal exposure endocrine disruptors dienestrol
Abstract: This study was aimed at determining whether dienestrol (DIES) affects reproduction in male offspring of rats following oral maternal exposure during gestation and lactation. Pregnant rats were treated from GD 6 to PND 21. Animals received 0 (control-vehicle), 0.75, 1.5, 3.12, 6.25, 12.5, 50, 75 μg/kg bw/d of DIES. A control group -without vehicle-was also included. High DIES concentrations caused abortions at 75 and 50 μg/kg bw/d, while at 12.5 μg/kg bw/d had still miscarriages. Ten male rats per group were kept alive until PND 90 to ensure sexual maturity. Body and organ weights, anogenital distance (AGD) at PNDs 21 and 90, biochemical and sperm parameters like motility, viability, morphology, spermatozoa and resistant spermatid counts, and histopathology for sexual organs and liver were determined. An increase in organ weight (liver and sexual organs) and a decrease in AGD due to vehicle were found. A reduction of sperm motility and viability, and an increase of abnormal sperm morphology were caused by DIES, which provoked a dose-dependent prostatitis. Maternal exposure to DIES induced toxicity on the reproductive system of the male offspring, which could affect the capacity of fertilization.
Thematic Areas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Author's mail: joseluis.domingo@urv.cat margarita.torrente@urv.cat
Author identifier: 0000-0001-6647-9470 0000-0002-8901-6345
Last page: 201
Record's date: 2025-02-19
Journal volume: 128
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Food And Chemical Toxicology. 128 193-201
APA: Schreiber, Elga; Alfageme, Oscar; Garcia, Tania; Gonzalez, Neus; Jose Sirvent, Juan; Torrente, Margarita; Gomez, Mercedes; Domingo, Jose L (2019). Oral exposure of rats to dienestrol during gestation and lactation: Effects on the reproductive system of male offspring. Food And Chemical Toxicology, 128(), 193-201. DOI: 10.1016/j.fct.2019.04.013
Entity: Universitat Rovira i Virgili
Journal publication year: 2019
First page: 193
Publication Type: Journal Publications
Repositori URV