Autor según el artículo: Schreiber, Elga; Alfageme, Oscar; Garcia, Tania; Gonzalez, Neus; Jose Sirvent, Juan; Torrente, Margarita; Gomez, Mercedes; Domingo, Jose L
Departamento: Bioquímica i Biotecnologia; Psicologia; Ciències Mèdiques Bàsiques
Autor/es de la URV: Domingo Roig, José Luis / Garcia Soldevila, Tània / Gómez Arnaiz, María Mercedes / Gonzalez Paradell, Nieves / Torrente Torné, Margarita
Palabras clave: Spermatozoa; Sperm motility; Sperm count; Sperm; Reproductive toxicity; Rats; Prostatitis; Pregnancy; Organ size; Maternal exposure; Male; Genitalia, male; Female; Estrogens, non-steroidal; Endocrine disruptors; Dose-response relationship, drug; Dienestrol; Body weight; Animals; Administration, oral; Abortion, veterinary; reproductive toxicity; maternal exposure; endocrine disruptors; dienestrol
Resumen: This study was aimed at determining whether dienestrol (DIES) affects reproduction in male offspring of rats following oral maternal exposure during gestation and lactation. Pregnant rats were treated from GD 6 to PND 21. Animals received 0 (control-vehicle), 0.75, 1.5, 3.12, 6.25, 12.5, 50, 75 μg/kg bw/d of DIES. A control group -without vehicle-was also included. High DIES concentrations caused abortions at 75 and 50 μg/kg bw/d, while at 12.5 μg/kg bw/d had still miscarriages. Ten male rats per group were kept alive until PND 90 to ensure sexual maturity. Body and organ weights, anogenital distance (AGD) at PNDs 21 and 90, biochemical and sperm parameters like motility, viability, morphology, spermatozoa and resistant spermatid counts, and histopathology for sexual organs and liver were determined. An increase in organ weight (liver and sexual organs) and a decrease in AGD due to vehicle were found. A reduction of sperm motility and viability, and an increase of abnormal sperm morphology were caused by DIES, which provoked a dose-dependent prostatitis. Maternal exposure to DIES induced toxicity on the reproductive system of the male offspring, which could affect the capacity of fertilization.
Áreas temáticas: Toxicology; Saúde coletiva; Química; Odontología; Nutrição; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Food science & technology; Food science; Farmacia; Ensino; Engenharias iv; Engenharias ii; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Direcció de correo del autor: joseluis.domingo@urv.cat; margarita.torrente@urv.cat
Página final: 201
Fecha de alta del registro: 2025-02-19
Volumen de revista: 128
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0278691519302121?via%3Dihub
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Food And Chemical Toxicology. 128 193-201
Referencia de l'ítem segons les normes APA: Schreiber, Elga; Alfageme, Oscar; Garcia, Tania; Gonzalez, Neus; Jose Sirvent, Juan; Torrente, Margarita; Gomez, Mercedes; Domingo, Jose L (2019). Oral exposure of rats to dienestrol during gestation and lactation: Effects on the reproductive system of male offspring. Food And Chemical Toxicology, 128(), 193-201. DOI: 10.1016/j.fct.2019.04.013
DOI del artículo: 10.1016/j.fct.2019.04.013
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Página inicial: 193
Tipo de publicación: Journal Publications
Repositori URV