Autor según el artículo: Schreiber E, Alfageme O, Garcia T, González N, Sirvent JJ, Torrente M, Gómez M, Domingo JL

Departamento: Ciències Mèdiques Bàsiques Psicologia Bioquímica i Biotecnologia

Autor/es de la URV: Domingo Roig, José Luis / Gómez Arnaiz, María Mercedes / Gonzalez Paradell, Nieves / Torrente Torné, Margarita

Palabras clave: Sperm Reproductive toxicity Maternal exposure Endocrine disruptors Dienestrol reproductive toxicity maternal exposure endocrine disruptors dienestrol

Resumen: This study was aimed at determining whether dienestrol (DIES) affects reproduction in male offspring of rats following oral maternal exposure during gestation and lactation. Pregnant rats were treated from GD 6 to PND 21. Animals received 0 (control-vehicle), 0.75, 1.5, 3.12, 6.25, 12.5, 50, 75 μg/kg bw/d of DIES. A control group -without vehicle-was also included. High DIES concentrations caused abortions at 75 and 50 μg/kg bw/d, while at 12.5 μg/kg bw/d had still miscarriages. Ten male rats per group were kept alive until PND 90 to ensure sexual maturity. Body and organ weights, anogenital distance (AGD) at PNDs 21 and 90, biochemical and sperm parameters like motility, viability, morphology, spermatozoa and resistant spermatid counts, and histopathology for sexual organs and liver were determined. An increase in organ weight (liver and sexual organs) and a decrease in AGD due to vehicle were found. A reduction of sperm motility and viability, and an increase of abnormal sperm morphology were caused by DIES, which provoked a dose-dependent prostatitis. Maternal exposure to DIES induced toxicity on the reproductive system of the male offspring, which could affect the capacity of fertilization.

Áreas temáticas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 02786915

Direcció de correo del autor: nieves.gonzalez@urv.cat margarita.torrente@urv.cat joseluis.domingo@urv.cat

Identificador del autor: 0000-0003-4134-016X 0000-0002-8901-6345 0000-0001-6647-9470

Página final: 201

Fecha de alta del registro: 2023-02-22

Volumen de revista: 128

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0278691519302121?via%3Dihub

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Food And Chemical Toxicology. 128 193-201

Referencia de l'ítem segons les normes APA: Schreiber E, Alfageme O, Garcia T, González N, Sirvent JJ, Torrente M, Gómez M, Domingo JL (2019). Oral exposure of rats to dienestrol during gestation and lactation: Effects on the reproductive system of male offspring. Food And Chemical Toxicology, 128(), 193-201. DOI: 10.1016/j.fct.2019.04.013

DOI del artículo: 10.1016/j.fct.2019.04.013

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Página inicial: 193

Tipo de publicación: Journal Publications