Autor segons l'article: Garcia-Algar, Manuel; Fernandez-Carrascal, Ana; Olano-Daza, Ana; Guerrini, Luca; Feliu, Neus; Parak, Wolfgang J; Guimera, Roger; Garcia-Rico, Eduardo; Alvarez-Puebla, Ramon A
Departament: Enginyeria Química
Autor/s de la URV: Alvarez Puebla, Ramon Angel / Guerrini, Luca / Guimera Manrique, Roger
Paraules clau: Hashtag Etiqueta «#» @uroweb @residentesaeu @infoAeu
Resum: In this manuscript, we demonstrate the applicability of a metabolic liquid biopsy for the monitoring and staging of patients with lung cancer. This method provides an unbiased detection strategy to establish a more precise correlation between CTC quantification and the actual burden of disease, therefore improving the accuracy of staging based on current imaging techniques. Also, by applying statistical analysis techniques and probabilistic models to the metabolic status and distribution of peripheral blood mononuclear cell (PBMC) populations 'perturbed' by the presence of CTCs, a new category of adaptive metabolic pattern biomarker (AMPB) is described and unambiguously correlated to the different clinical stages of the patients. In fact, this strategy allows for classification of different categories of disease within a single stage (stage IV) before computed tomography (CT) and positron emission tomography (PET) scans and with lower uncertainty.
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2397-768X
Adreça de correu electrònic de l'autor: roger.guimera@urv.cat ramon.alvarez@urv.cat luca.guerrini@urv.cat
Identificador de l'autor: 0000-0002-3597-4310 0000-0003-4770-5756 0000-0002-2925-1562
Data d'alta del registre: 2024-10-26
Volum de revista: 2
Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
Enllaç font original: https://www.nature.com/articles/s41698-018-0059-9
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Npj Precision Oncology. 2 (1): 16-
Referència de l'ítem segons les normes APA: Garcia-Algar, Manuel; Fernandez-Carrascal, Ana; Olano-Daza, Ana; Guerrini, Luca; Feliu, Neus; Parak, Wolfgang J; Guimera, Roger; Garcia-Rico, Eduardo; (2018). Adaptive metabolic pattern biomarker for disease monitoring and staging of lung cancer with liquid biopsy. Npj Precision Oncology, 2(1), 16-. DOI: 10.1038/s41698-018-0059-9
DOI de l'article: 10.1038/s41698-018-0059-9
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Pàgina inicial: Article number 16
Tipus de publicació: Journal Publications
Repositori URV