Autor segons l'article: Erenas M; Ortiz-Gómez I; De Orbe-Payá I; Hernández-Alonso D; Ballester P; Blondeau P; Andrade F; Salinas-Castillo A; Capitán-Vallvey L
Departament: Química Analítica i Química Orgànica
Autor/s de la URV: Andrade, Francisco Javier / Blondeau, Pascal Jean Claude Leon
Codi de projecte: CTQ2016-77128-R
Paraules clau: Spectrometry Optode Host?guest chemistry Disposable sensor Calix[6]pyrrole Biofluids optode host?guest chemistry disposable sensor calix[6]pyrrole biofluids
Resum: © 2019 American Chemical Society. Creatinine is a metabolite present in urine, and its concentration is used to diagnose and monitor kidney performance. For that reason, the development of new sensors to analyze this metabolite and obtain accurate results in a short period of time is necessary. An optical disposable sensor for monitoring creatinine levels in urine is described. The system, based on a new aryl-substituted calix[4]pyrrole synthetic receptor, has an unusual coextraction scheme. Due to the low pK a values of creatininium (pK a 4.8), a careful selection of a lipophilic pH indicator that works in acid medium is required. The sensor components were optimized, and the new sensor displays a good response time to creatinine (approximately 3 min) over a wide dynamic range (from 1 × 10 -5 to 1 × 10 -2 M). Moreover, the optical selectivity coefficients obtained for creatinine over common cations present in urine meet the requirements for real sample measurements. With a good sensor-To-sensor reproducibility (RSD, 5.1-6.9% in the middle of the range), this method provides a simple, quick, cost-effective, and selective alternative to the conventional methodology based on Jaffé's reaction.
Àrees temàtiques: Process chemistry and technology Nanoscience & nanotechnology Instrumentation Fluid flow and transfer processes Engenharias iii Chemistry, multidisciplinary Chemistry, analytical Bioengineering
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 23793694
Adreça de correu electrònic de l'autor: pascal.blondeau@urv.cat franciscojavier.andrade@urv.cat
Identificador de l'autor: 0000-0003-1331-5055 0000-0003-1199-2837
Data d'alta del registre: 2023-02-18
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://pubs.acs.org/doi/10.1021/acssensors.8b01378
Programa de finançament: Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (Agencia Estatal de Investigación - Ministerio de Economía, Industria y Competitividad)
URL Document de llicència: http://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Acs Sensors. 4 (2): 421-426
Referència de l'ítem segons les normes APA: Erenas M; Ortiz-Gómez I; De Orbe-Payá I; Hernández-Alonso D; Ballester P; Blondeau P; Andrade F; Salinas-Castillo A; Capitán-Vallvey L (2019). Ionophore-based optical sensor for urine creatinine determination. Acs Sensors, 4(2), 421-426. DOI: 10.1021/acssensors.8b01378
Acrònim: HOMESENS
DOI de l'article: 10.1021/acssensors.8b01378
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2019
Acció del programa de finançament: Proyecto de I+D
Tipus de publicació: Journal Publications
Repositori URV