Articles producció científica> Química Analítica i Química Orgànica

Ionophore-based optical sensor for urine creatinine determination

  • Datos identificativos

    Identificador: imarina:5611015
    Autores:
    Erenas MOrtiz-Gómez IDe Orbe-Payá IHernández-Alonso DBallester PBlondeau PAndrade FSalinas-Castillo ACapitán-Vallvey L
    Resumen:
    © 2019 American Chemical Society. Creatinine is a metabolite present in urine, and its concentration is used to diagnose and monitor kidney performance. For that reason, the development of new sensors to analyze this metabolite and obtain accurate results in a short period of time is necessary. An optical disposable sensor for monitoring creatinine levels in urine is described. The system, based on a new aryl-substituted calix[4]pyrrole synthetic receptor, has an unusual coextraction scheme. Due to the low pK a values of creatininium (pK a 4.8), a careful selection of a lipophilic pH indicator that works in acid medium is required. The sensor components were optimized, and the new sensor displays a good response time to creatinine (approximately 3 min) over a wide dynamic range (from 1 × 10 -5 to 1 × 10 -2 M). Moreover, the optical selectivity coefficients obtained for creatinine over common cations present in urine meet the requirements for real sample measurements. With a good sensor-To-sensor reproducibility (RSD, 5.1-6.9% in the middle of the range), this method provides a simple, quick, cost-effective, and selective alternative to the conventional methodology based on Jaffé's reaction.
  • Otros:

    Autor según el artículo: Erenas M; Ortiz-Gómez I; De Orbe-Payá I; Hernández-Alonso D; Ballester P; Blondeau P; Andrade F; Salinas-Castillo A; Capitán-Vallvey L
    Departamento: Química Analítica i Química Orgànica
    Autor/es de la URV: Andrade, Francisco Javier / Blondeau, Pascal Jean Claude Leon
    Código de proyecto: CTQ2016-77128-R
    Palabras clave: Spectrometry Optode Host?guest chemistry Disposable sensor Calix[6]pyrrole Biofluids optode host?guest chemistry disposable sensor calix[6]pyrrole biofluids
    Resumen: © 2019 American Chemical Society. Creatinine is a metabolite present in urine, and its concentration is used to diagnose and monitor kidney performance. For that reason, the development of new sensors to analyze this metabolite and obtain accurate results in a short period of time is necessary. An optical disposable sensor for monitoring creatinine levels in urine is described. The system, based on a new aryl-substituted calix[4]pyrrole synthetic receptor, has an unusual coextraction scheme. Due to the low pK a values of creatininium (pK a 4.8), a careful selection of a lipophilic pH indicator that works in acid medium is required. The sensor components were optimized, and the new sensor displays a good response time to creatinine (approximately 3 min) over a wide dynamic range (from 1 × 10 -5 to 1 × 10 -2 M). Moreover, the optical selectivity coefficients obtained for creatinine over common cations present in urine meet the requirements for real sample measurements. With a good sensor-To-sensor reproducibility (RSD, 5.1-6.9% in the middle of the range), this method provides a simple, quick, cost-effective, and selective alternative to the conventional methodology based on Jaffé's reaction.
    Áreas temáticas: Process chemistry and technology Nanoscience & nanotechnology Instrumentation Fluid flow and transfer processes Engenharias iii Chemistry, multidisciplinary Chemistry, analytical Bioengineering
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 23793694
    Direcció de correo del autor: pascal.blondeau@urv.cat franciscojavier.andrade@urv.cat
    Identificador del autor: 0000-0003-1331-5055 0000-0003-1199-2837
    Fecha de alta del registro: 2023-02-18
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://pubs.acs.org/doi/10.1021/acssensors.8b01378
    Programa de financiación: Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (Agencia Estatal de Investigación - Ministerio de Economía, Industria y Competitividad)
    Referencia al articulo segun fuente origial: Acs Sensors. 4 (2): 421-426
    Referencia de l'ítem segons les normes APA: Erenas M; Ortiz-Gómez I; De Orbe-Payá I; Hernández-Alonso D; Ballester P; Blondeau P; Andrade F; Salinas-Castillo A; Capitán-Vallvey L (2019). Ionophore-based optical sensor for urine creatinine determination. Acs Sensors, 4(2), 421-426. DOI: 10.1021/acssensors.8b01378
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Acrónimo: HOMESENS
    DOI del artículo: 10.1021/acssensors.8b01378
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2019
    Acción del progama de financiación: Proyecto de I+D
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Bioengineering,Chemistry, Analytical,Chemistry, Multidisciplinary,Fluid Flow and Transfer Processes,Instrumentation,Nanoscience & Nanotechnology,Process Chemistry and Technology
    Spectrometry
    Optode
    Host?guest chemistry
    Disposable sensor
    Calix[6]pyrrole
    Biofluids
    optode
    host?guest chemistry
    disposable sensor
    calix[6]pyrrole
    biofluids
    Process chemistry and technology
    Nanoscience & nanotechnology
    Instrumentation
    Fluid flow and transfer processes
    Engenharias iii
    Chemistry, multidisciplinary
    Chemistry, analytical
    Bioengineering
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