Autor según el artículo: Erenas M; Ortiz-Gómez I; De Orbe-Payá I; Hernández-Alonso D; Ballester P; Blondeau P; Andrade F; Salinas-Castillo A; Capitán-Vallvey L

Departamento: Química Analítica i Química Orgànica

Autor/es de la URV: Andrade, Francisco Javier / Blondeau, Pascal Jean Claude Leon

Código de proyecto: CTQ2016-77128-R

Palabras clave: Spectrometry Optode Host?guest chemistry Disposable sensor Calix[6]pyrrole Biofluids optode host?guest chemistry disposable sensor calix[6]pyrrole biofluids

Resumen: © 2019 American Chemical Society. Creatinine is a metabolite present in urine, and its concentration is used to diagnose and monitor kidney performance. For that reason, the development of new sensors to analyze this metabolite and obtain accurate results in a short period of time is necessary. An optical disposable sensor for monitoring creatinine levels in urine is described. The system, based on a new aryl-substituted calix[4]pyrrole synthetic receptor, has an unusual coextraction scheme. Due to the low pK a values of creatininium (pK a 4.8), a careful selection of a lipophilic pH indicator that works in acid medium is required. The sensor components were optimized, and the new sensor displays a good response time to creatinine (approximately 3 min) over a wide dynamic range (from 1 × 10 -5 to 1 × 10 -2 M). Moreover, the optical selectivity coefficients obtained for creatinine over common cations present in urine meet the requirements for real sample measurements. With a good sensor-To-sensor reproducibility (RSD, 5.1-6.9% in the middle of the range), this method provides a simple, quick, cost-effective, and selective alternative to the conventional methodology based on Jaffé's reaction.

Áreas temáticas: Process chemistry and technology Nanoscience & nanotechnology Instrumentation Fluid flow and transfer processes Engenharias iii Chemistry, multidisciplinary Chemistry, analytical Bioengineering

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 23793694

Direcció de correo del autor: pascal.blondeau@urv.cat franciscojavier.andrade@urv.cat

Identificador del autor: 0000-0003-1331-5055 0000-0003-1199-2837

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://pubs.acs.org/doi/10.1021/acssensors.8b01378

Programa de financiación: Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (Agencia Estatal de Investigación - Ministerio de Economía, Industria y Competitividad)

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Acs Sensors. 4 (2): 421-426

Referencia de l'ítem segons les normes APA: Erenas M; Ortiz-Gómez I; De Orbe-Payá I; Hernández-Alonso D; Ballester P; Blondeau P; Andrade F; Salinas-Castillo A; Capitán-Vallvey L (2019). Ionophore-based optical sensor for urine creatinine determination. Acs Sensors, 4(2), 421-426. DOI: 10.1021/acssensors.8b01378

Acrónimo: HOMESENS

DOI del artículo: 10.1021/acssensors.8b01378

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2019

Acción del progama de financiación: Proyecto de I+D

Tipo de publicación: Journal Publications