Autor segons l'article: Giardina, Simona; Hernandez-Alonso, Pablo; Salas-Salvado, Jordi; Rabassa-Soler, Antoni; Bullo, Monica
Departament: Bioquímica i Biotecnologia
Autor/s de la URV: Bulló Bonet, Mònica / Rabassa Soler, Antonio / Salas Salvadó, Jorge
Paraules clau: Waist circumference Transcriptome Subcutaneous fat Post-transcriptional regulation Overweight Obesity Micrornas Male Humans High-throughput Glycemic index Female Diet, fat-restricted Diet Carbohydrates Caloric restriction Body weight Adult Adiposity obesity high-throughput diet carbohydrates
Resum: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: To analyze the effect of three calorie-restricted diets with different amount and quality of carbohydrates on subcutaneous adipose tissue (SAT) microRNA (miRNA) profile. Methods and results: 6-month parallel, randomized trial conducted on overweight and obese subjects randomized to: 1) low glycemic index diet (LGI), 2) high glycemic index diet (HGI), and 3) low-fat (LF). The genome-wide SAT miRNA profile was assessed in eight randomly selected participants and the most relevant changing miRNAs (n = 13) were validated in 48 subjects. None of the miRNAs showed significant changes between the intervention groups. However, changes in some of them correlated with changes in biochemical and anthropometric variables. Stratifying our population according to tertiles of percentage change in body weight (BW), we observed a significant down-regulation of miR-210 in those subjects in Tertile 1 as compared to Tertile 3. When our population was stratified by tertiles of waist circumference, miR-132, miR-29a, miR-34a, and miR-378 were found to be significantly down-regulated, in T2 compared to T3. Furthermore, when stratified by tertiles of fat mass, we also observed the significant down-regulation of miR-132 in T1. Conclusion: The macronutrient composition of a calorie-restricted diet does not affect the expression of the miRNAs analyzed, while changes in adiposity play a primary regulatory role.
Àrees temàtiques: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Adreça de correu electrònic de l'autor: antonio.rabassa@urv.cat monica.bullo@urv.cat jordi.salas@urv.cat
Identificador de l'autor: 0000-0002-0218-7046 0000-0003-2700-7459
Data d'alta del registre: 2024-10-12
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.201700594
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Molecular Nutrition & Food Research. 62 (2): 1700594-
Referència de l'ítem segons les normes APA: Giardina, Simona; Hernandez-Alonso, Pablo; Salas-Salvado, Jordi; Rabassa-Soler, Antoni; Bullo, Monica (2018). Modulation of Human Subcutaneous Adipose Tissue MicroRNA Profile Associated with Changes in Adiposity-Related Parameters. Molecular Nutrition & Food Research, 62(2), 1700594-. DOI: 10.1002/mnfr.201700594
DOI de l'article: 10.1002/mnfr.201700594
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2018
Tipus de publicació: Journal Publications