Autor segons l'article: Perez-Cantero, Alba; Lopez-Fernandez, Loida; Guarro, Josep; Capilla, Javier
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / LÓPEZ FERNÁNDEZ, LOIDA / PÉREZ CANTERO, ALBA
Paraules clau: Voriconazole resistance; Voriconazole; Triazoles; Triazole resistance; Major facilitator superfamily; Itraconazole resistance; In-vitro; Humans; Fungal proteins; Fumigatus; Eucast technical note; Efflux pumps; Drug resistance, fungal; Cytochrome p450 family 51; Cyp51; Cross-resistance; Azoles; Atp-binding cassette transporters; Aspergillus fumigatus; Aspergillus; Aspergillosis; Antifungal resistance; Antifungal drug-resistance; Antifungal agents; 14-alpha-sterol demethylase cyp51a
Resum: Aspergillus fumigatus is the main causal agent of invasive aspergillosis (IA) although other species of the genus can also be the cause of IA, such as A. flavus, A. terreus, A. niger and related cryptic species. This infectious disease mainly affects immunosuppressed patients and it is linked to elevated mortality rates. Being voriconazole (VRC) the treatment of choice for this condition, the relevant increase in the number of azole resistant isolates in recent years has gathered alarming attention, as it translates into a clinical failure increment as well. In this review, we summarize and discuss the azole resistance molecular data described to date in the most clinically prevalent sections of Aspergillus, comprising mechanisms that involve target proteins Cyp51 and ATP Binding Cassette (ABC) or Major Facilitator Superfamily (MFS) efflux pumps. Other resistance mechanisms proposed but not fully-characterized yet are also discussed.Copyright © 2019. Published by Elsevier B.V.
Àrees temàtiques: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Odontología; Nutrição; Microbiology (medical); Microbiology; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Infectious diseases; General medicine; Farmacia; Engenharias iii; Engenharias ii; Enfermagem; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Biotecnología; Biodiversidade
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09248579
Adreça de correu electrònic de l'autor: javier.capilla@urv.cat
Data d'alta del registre: 2025-01-08
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0924857919302547?via%3Dihub
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: International Journal Of Antimicrobial Agents. 55 (1): 105807-
Referència de l'ítem segons les normes APA: Perez-Cantero, Alba; Lopez-Fernandez, Loida; Guarro, Josep; Capilla, Javier (2020). Update and recent advances on azole resistance mechanisms in Aspergillus. International Journal Of Antimicrobial Agents, 55(1), 105807-. DOI: 10.1016/j.ijantimicag.2019.09.011
DOI de l'article: 10.1016/j.ijantimicag.2019.09.011
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2020
Tipus de publicació: Journal Publications
Repositori URV