Author, as appears in the article.: Perez-Cantero, Alba; Lopez-Fernandez, Loida; Guarro, Josep; Capilla, Javier
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep / LÓPEZ FERNÁNDEZ, LOIDA / PÉREZ CANTERO, ALBA
Keywords: Voriconazole resistance Voriconazole Triazoles Triazole resistance Major facilitator superfamily Itraconazole resistance In-vitro Humans Fungal proteins Fumigatus Eucast technical note Efflux pumps Drug resistance, fungal Cytochrome p450 family 51 Cyp51 Cross-resistance Azoles Atp-binding cassette transporters Aspergillus fumigatus Aspergillus Aspergillosis Antifungal resistance Antifungal drug-resistance Antifungal agents 14-alpha-sterol demethylase cyp51a
Abstract: Aspergillus fumigatus is the main causal agent of invasive aspergillosis (IA) although other species of the genus can also be the cause of IA, such as A. flavus, A. terreus, A. niger and related cryptic species. This infectious disease mainly affects immunosuppressed patients and it is linked to elevated mortality rates. Being voriconazole (VRC) the treatment of choice for this condition, the relevant increase in the number of azole resistant isolates in recent years has gathered alarming attention, as it translates into a clinical failure increment as well. In this review, we summarize and discuss the azole resistance molecular data described to date in the most clinically prevalent sections of Aspergillus, comprising mechanisms that involve target proteins Cyp51 and ATP Binding Cassette (ABC) or Major Facilitator Superfamily (MFS) efflux pumps. Other resistance mechanisms proposed but not fully-characterized yet are also discussed.Copyright © 2019. Published by Elsevier B.V.
Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Odontología Nutrição Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases General medicine Farmacia Engenharias iii Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09248579
Author's mail: javier.capilla@urv.cat
Author identifier: 0000-0002-0765-6403
Record's date: 2025-01-08
Paper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: International Journal Of Antimicrobial Agents. 55 (1): 105807-
APA: Perez-Cantero, Alba; Lopez-Fernandez, Loida; Guarro, Josep; Capilla, Javier (2020). Update and recent advances on azole resistance mechanisms in Aspergillus. International Journal Of Antimicrobial Agents, 55(1), 105807-. DOI: 10.1016/j.ijantimicag.2019.09.011
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV