Autor según el artículo: Perez-Cantero, Alba; Lopez-Fernandez, Loida; Guarro, Josep; Capilla, Javier
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / LÓPEZ FERNÁNDEZ, LOIDA / PÉREZ CANTERO, ALBA
Palabras clave: Voriconazole resistance; Voriconazole; Triazoles; Triazole resistance; Major facilitator superfamily; Itraconazole resistance; In-vitro; Humans; Fungal proteins; Fumigatus; Eucast technical note; Efflux pumps; Drug resistance, fungal; Cytochrome p450 family 51; Cyp51; Cross-resistance; Azoles; Atp-binding cassette transporters; Aspergillus fumigatus; Aspergillus; Aspergillosis; Antifungal resistance; Antifungal drug-resistance; Antifungal agents; 14-alpha-sterol demethylase cyp51a
Resumen: Aspergillus fumigatus is the main causal agent of invasive aspergillosis (IA) although other species of the genus can also be the cause of IA, such as A. flavus, A. terreus, A. niger and related cryptic species. This infectious disease mainly affects immunosuppressed patients and it is linked to elevated mortality rates. Being voriconazole (VRC) the treatment of choice for this condition, the relevant increase in the number of azole resistant isolates in recent years has gathered alarming attention, as it translates into a clinical failure increment as well. In this review, we summarize and discuss the azole resistance molecular data described to date in the most clinically prevalent sections of Aspergillus, comprising mechanisms that involve target proteins Cyp51 and ATP Binding Cassette (ABC) or Major Facilitator Superfamily (MFS) efflux pumps. Other resistance mechanisms proposed but not fully-characterized yet are also discussed.Copyright © 2019. Published by Elsevier B.V.
Áreas temáticas: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Odontología; Nutrição; Microbiology (medical); Microbiology; Medicine (miscellaneous); Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Infectious diseases; General medicine; Farmacia; Engenharias iii; Engenharias ii; Enfermagem; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Biotecnología; Biodiversidade
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 09248579
Direcció de correo del autor: javier.capilla@urv.cat
Fecha de alta del registro: 2025-01-08
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0924857919302547?via%3Dihub
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: International Journal Of Antimicrobial Agents. 55 (1): 105807-
Referencia de l'ítem segons les normes APA: Perez-Cantero, Alba; Lopez-Fernandez, Loida; Guarro, Josep; Capilla, Javier (2020). Update and recent advances on azole resistance mechanisms in Aspergillus. International Journal Of Antimicrobial Agents, 55(1), 105807-. DOI: 10.1016/j.ijantimicag.2019.09.011
DOI del artículo: 10.1016/j.ijantimicag.2019.09.011
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV