Articles producció científica> Ciències Mèdiques Bàsiques

Update and recent advances on azole resistance mechanisms in Aspergillus

  • Datos identificativos

    Identificador: imarina:5873560
    Autores:
    Pérez-Cantero A, López-Fernández L, Guarro J, Capilla J
    Resumen:
    Aspergillus fumigatus is the main causal agent of invasive aspergillosis (IA) although other species of the genus can also be the cause of IA, such as A. flavus, A. terreus, A. niger and related cryptic species. This infectious disease mainly affects immunosuppressed patients and it is linked to elevated mortality rates. Being voriconazole (VRC) the treatment of choice for this condition, the relevant increase in the number of azole resistant isolates in recent years has gathered alarming attention, as it translates into a clinical failure increment as well. In this review, we summarize and discuss the azole resistance molecular data described to date in the most clinically prevalent sections of Aspergillus, comprising mechanisms that involve target proteins Cyp51 and ATP Binding Cassette (ABC) or Major Facilitator Superfamily (MFS) efflux pumps. Other resistance mechanisms proposed but not fully-characterized yet are also discussed.Copyright © 2019. Published by Elsevier B.V.
  • Otros:

    Autor según el artículo: Pérez-Cantero A, López-Fernández L, Guarro J, Capilla J
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Capilla Luque, Javier / Guarro Artigas, Josep / LÓPEZ FERNÁNDEZ, LOIDA / PÉREZ CANTERO, ALBA
    Palabras clave: Voriconazole resistance Triazoles Triazole resistance Major facilitator superfamily Itraconazole resistance In-vitro Fumigatus Eucast technical note Efflux pumps Cyp51 Cross-resistance Aspergillosis Antifungal resistance Antifungal drug-resistance 14-alpha-sterol demethylase cyp51a
    Resumen: Aspergillus fumigatus is the main causal agent of invasive aspergillosis (IA) although other species of the genus can also be the cause of IA, such as A. flavus, A. terreus, A. niger and related cryptic species. This infectious disease mainly affects immunosuppressed patients and it is linked to elevated mortality rates. Being voriconazole (VRC) the treatment of choice for this condition, the relevant increase in the number of azole resistant isolates in recent years has gathered alarming attention, as it translates into a clinical failure increment as well. In this review, we summarize and discuss the azole resistance molecular data described to date in the most clinically prevalent sections of Aspergillus, comprising mechanisms that involve target proteins Cyp51 and ATP Binding Cassette (ABC) or Major Facilitator Superfamily (MFS) efflux pumps. Other resistance mechanisms proposed but not fully-characterized yet are also discussed.Copyright © 2019. Published by Elsevier B.V.
    Áreas temáticas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Odontología Nutrição Microbiology (medical) Microbiology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases General medicine Farmacia Engenharias iii Engenharias ii Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 09248579
    Direcció de correo del autor: josep.guarro@urv.cat javier.capilla@urv.cat
    Identificador del autor: 0000-0002-7839-7568 0000-0002-0765-6403
    Fecha de alta del registro: 2023-02-18
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0924857919302547?via%3Dihub
    Referencia al articulo segun fuente origial: International Journal Of Antimicrobial Agents. 55 (1): 105807-
    Referencia de l'ítem segons les normes APA: Pérez-Cantero A, López-Fernández L, Guarro J, Capilla J (2020). Update and recent advances on azole resistance mechanisms in Aspergillus. International Journal Of Antimicrobial Agents, 55(1), 105807-. DOI: 10.1016/j.ijantimicag.2019.09.011
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1016/j.ijantimicag.2019.09.011
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Infectious Diseases,Medicine (Miscellaneous),Microbiology,Microbiology (Medical),Pharmacology & Pharmacy,Pharmacology (Medical)
    Voriconazole resistance
    Triazoles
    Triazole resistance
    Major facilitator superfamily
    Itraconazole resistance
    In-vitro
    Fumigatus
    Eucast technical note
    Efflux pumps
    Cyp51
    Cross-resistance
    Aspergillosis
    Antifungal resistance
    Antifungal drug-resistance
    14-alpha-sterol demethylase cyp51a
    Saúde coletiva
    Química
    Pharmacology (medical)
    Pharmacology & pharmacy
    Odontología
    Nutrição
    Microbiology (medical)
    Microbiology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Infectious diseases
    General medicine
    Farmacia
    Engenharias iii
    Engenharias ii
    Enfermagem
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
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