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Cyanidin-3-glucoside as a possible biomarker for anthocyanin-rich berry intake in body fluids of healthy humans: a systematic review of clinical trials.

  • Dades identificatives

    Identificador: imarina:6040440
    Autors:
    Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Pedret A, Llauradó E, Solà R.
    Resum:
    Anthocyanins are phenolic compounds found in berries. They exhibit promising health benefits in humans, but no accurate biomarkers of berry intake have been identified thus far.The aim of this systematic review is to propose a biomarker of anthocyanin-rich berry intake in human plasma and urine.PubMed and Cochrane databases were searched from January 2008 to January 2019.Databases were searched for human intervention studies that assessed the presence of anthocyanins in human body fluids using high-throughput techniques. Non-English articles and studies publishing targeted analyses were excluded.Ten clinical trials, in which 203 phenolic compounds were identified, were included and assessed qualitatively. The following criteria were used to identify biomarkers of berry intake: frequency, plausibility, dose-response, time response, robustness, reliability, stability, analytical performance, and reproducibility. Sensitivity and specificity of potential biomarkers were determined by the receiver operating characteristic curve.Of the 203 phenolic compounds identified in human samples, the anthocyanin cyanidin-3-glucoside was the molecule found most frequently in urine (58.06%) and plasma (69.49%). Cyanidin-3-glucoside fulfills the essential criterion of plausibility as well as the dose-response, time response, stability, and analytical performance criteria. Its positive predictive value is 74% (P?=?0.210) in plasma, which is acceptable, and 61.7% (P?=?0.402) in urine.Current evidence suggests that cyanidin-3-glucoside is a potential biomarker of anthocyanin-rich berry intake in plasma and urine of healthy humans.CRD42018096796.© The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute.
  • Altres:

    Autor segons l'article: Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Pedret A, Llauradó E, Solà R.
    Departament: Medicina i Cirurgia
    Autor/s de la URV: Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / Llauradó Ribé, Elisabet / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria
    Codi de projecte: 713679
    Paraules clau: Urine Raspberry Polyphenols Plasma Phenolic-compounds Pharmacokinetics Metabolites Fruit Diet Cyanidin-3-glucoside Cyanidin 3-glucoside Blackberry anthocyanins Biomarker Bioavailability Berry Anthocyanins plasma cyanidin-3-glucoside biomarker berry anthocyanins
    Resum: Anthocyanins are phenolic compounds found in berries. They exhibit promising health benefits in humans, but no accurate biomarkers of berry intake have been identified thus far.The aim of this systematic review is to propose a biomarker of anthocyanin-rich berry intake in human plasma and urine.PubMed and Cochrane databases were searched from January 2008 to January 2019.Databases were searched for human intervention studies that assessed the presence of anthocyanins in human body fluids using high-throughput techniques. Non-English articles and studies publishing targeted analyses were excluded.Ten clinical trials, in which 203 phenolic compounds were identified, were included and assessed qualitatively. The following criteria were used to identify biomarkers of berry intake: frequency, plausibility, dose-response, time response, robustness, reliability, stability, analytical performance, and reproducibility. Sensitivity and specificity of potential biomarkers were determined by the receiver operating characteristic curve.Of the 203 phenolic compounds identified in human samples, the anthocyanin cyanidin-3-glucoside was the molecule found most frequently in urine (58.06%) and plasma (69.49%). Cyanidin-3-glucoside fulfills the essential criterion of plausibility as well as the dose-response, time response, stability, and analytical performance criteria. Its positive predictive value is 74% (P?=?0.210) in plasma, which is acceptable, and 61.7% (P?=?0.402) in urine.Current evidence suggests that cyanidin-3-glucoside is a potential biomarker of anthocyanin-rich berry intake in plasma and urine of healthy humans.CRD42018096796.© The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute.
    Àrees temàtiques: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Biotecnología
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00296643
    Adreça de correu electrònic de l'autor: elisabet.llaurado@urv.cat ursula.catalan@urv.cat rosa.sola@urv.cat
    Identificador de l'autor: 0000-0002-7439-9531 0000-0001-8884-9823 0000-0002-8359-235X
    Data d'alta del registre: 2023-07-31
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    Enllaç font original: https://academic.oup.com/nutritionreviews/article/78/7/597/5681776
    Programa de finançament: Marie Skłodowska-Curie Actions - European Union's Horizon 2020 research and innovation programme
    Referència a l'article segons font original: Nutrition Reviews. 78 (7): 597-610
    Referència de l'ítem segons les normes APA: Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Pedret A, Llauradó E, Solà R. (2020). Cyanidin-3-glucoside as a possible biomarker for anthocyanin-rich berry intake in body fluids of healthy humans: a systematic review of clinical trials.. Nutrition Reviews, 78(7), 597-610. DOI: 10.1093/nutrit/nuz083
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Acrònim: MFP
    DOI de l'article: 10.1093/nutrit/nuz083
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Acció del programa de finançament: Martí i Franquès COFUND Doctoral Programme
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Urine
    Raspberry
    Polyphenols
    Plasma
    Phenolic-compounds
    Pharmacokinetics
    Metabolites
    Fruit
    Diet
    Cyanidin-3-glucoside
    Cyanidin 3-glucoside
    Blackberry anthocyanins
    Biomarker
    Bioavailability
    Berry
    Anthocyanins
    plasma
    cyanidin-3-glucoside
    biomarker
    berry
    anthocyanins
    Saúde coletiva
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicine (all)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Biotecnología
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