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Cyanidin-3-glucoside as a possible biomarker for anthocyanin-rich berry intake in body fluids of healthy humans: a systematic review of clinical trials.

  • Datos identificativos

    Identificador: imarina:6040440
    Autores:
    Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Pedret A, Llauradó E, Solà R.
    Resumen:
    Anthocyanins are phenolic compounds found in berries. They exhibit promising health benefits in humans, but no accurate biomarkers of berry intake have been identified thus far.The aim of this systematic review is to propose a biomarker of anthocyanin-rich berry intake in human plasma and urine.PubMed and Cochrane databases were searched from January 2008 to January 2019.Databases were searched for human intervention studies that assessed the presence of anthocyanins in human body fluids using high-throughput techniques. Non-English articles and studies publishing targeted analyses were excluded.Ten clinical trials, in which 203 phenolic compounds were identified, were included and assessed qualitatively. The following criteria were used to identify biomarkers of berry intake: frequency, plausibility, dose-response, time response, robustness, reliability, stability, analytical performance, and reproducibility. Sensitivity and specificity of potential biomarkers were determined by the receiver operating characteristic curve.Of the 203 phenolic compounds identified in human samples, the anthocyanin cyanidin-3-glucoside was the molecule found most frequently in urine (58.06%) and plasma (69.49%). Cyanidin-3-glucoside fulfills the essential criterion of plausibility as well as the dose-response, time response, stability, and analytical performance criteria. Its positive predictive value is 74% (P?=?0.210) in plasma, which is acceptable, and 61.7% (P?=?0.402) in urine.Current evidence suggests that cyanidin-3-glucoside is a potential biomarker of anthocyanin-rich berry intake in plasma and urine of healthy humans.CRD42018096796.© The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute.
  • Otros:

    Autor según el artículo: Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Pedret A, Llauradó E, Solà R.
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Catalán Santos, Úrsula / FERNÁNDEZ CASTILLEJO, SARA / Llauradó Ribé, Elisabet / SANDOVAL RAMÍREZ, BERNER ANDRÉE / Solà Alberich, Rosa Maria
    Código de proyecto: 713679
    Palabras clave: Urine Raspberry Polyphenols Plasma Phenolic-compounds Pharmacokinetics Metabolites Fruit Diet Cyanidin-3-glucoside Cyanidin 3-glucoside Blackberry anthocyanins Biomarker Bioavailability Berry Anthocyanins plasma cyanidin-3-glucoside biomarker berry anthocyanins
    Resumen: Anthocyanins are phenolic compounds found in berries. They exhibit promising health benefits in humans, but no accurate biomarkers of berry intake have been identified thus far.The aim of this systematic review is to propose a biomarker of anthocyanin-rich berry intake in human plasma and urine.PubMed and Cochrane databases were searched from January 2008 to January 2019.Databases were searched for human intervention studies that assessed the presence of anthocyanins in human body fluids using high-throughput techniques. Non-English articles and studies publishing targeted analyses were excluded.Ten clinical trials, in which 203 phenolic compounds were identified, were included and assessed qualitatively. The following criteria were used to identify biomarkers of berry intake: frequency, plausibility, dose-response, time response, robustness, reliability, stability, analytical performance, and reproducibility. Sensitivity and specificity of potential biomarkers were determined by the receiver operating characteristic curve.Of the 203 phenolic compounds identified in human samples, the anthocyanin cyanidin-3-glucoside was the molecule found most frequently in urine (58.06%) and plasma (69.49%). Cyanidin-3-glucoside fulfills the essential criterion of plausibility as well as the dose-response, time response, stability, and analytical performance criteria. Its positive predictive value is 74% (P?=?0.210) in plasma, which is acceptable, and 61.7% (P?=?0.402) in urine.Current evidence suggests that cyanidin-3-glucoside is a potential biomarker of anthocyanin-rich berry intake in plasma and urine of healthy humans.CRD42018096796.© The Author(s) 2019. Published by Oxford University Press on behalf of the International Life Sciences Institute.
    Áreas temáticas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00296643
    Direcció de correo del autor: elisabet.llaurado@urv.cat ursula.catalan@urv.cat rosa.sola@urv.cat
    Identificador del autor: 0000-0002-7439-9531 0000-0001-8884-9823 0000-0002-8359-235X
    Fecha de alta del registro: 2023-07-31
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://academic.oup.com/nutritionreviews/article/78/7/597/5681776
    Programa de financiación: Marie Skłodowska-Curie Actions - European Union's Horizon 2020 research and innovation programme
    Referencia al articulo segun fuente origial: Nutrition Reviews. 78 (7): 597-610
    Referencia de l'ítem segons les normes APA: Sandoval-Ramírez BA, Catalán Ú, Fernández-Castillejo S, Pedret A, Llauradó E, Solà R. (2020). Cyanidin-3-glucoside as a possible biomarker for anthocyanin-rich berry intake in body fluids of healthy humans: a systematic review of clinical trials.. Nutrition Reviews, 78(7), 597-610. DOI: 10.1093/nutrit/nuz083
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Acrónimo: MFP
    DOI del artículo: 10.1093/nutrit/nuz083
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Acción del progama de financiación: Martí i Franquès COFUND Doctoral Programme
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Urine
    Raspberry
    Polyphenols
    Plasma
    Phenolic-compounds
    Pharmacokinetics
    Metabolites
    Fruit
    Diet
    Cyanidin-3-glucoside
    Cyanidin 3-glucoside
    Blackberry anthocyanins
    Biomarker
    Bioavailability
    Berry
    Anthocyanins
    plasma
    cyanidin-3-glucoside
    biomarker
    berry
    anthocyanins
    Saúde coletiva
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicine (all)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Biotecnología
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