Articles producció científica> Ciències Mèdiques Bàsiques

In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis

  • Dades identificatives

    Identificador: imarina:6063226
    Autors:
    Martin-Vicente, AdelaCapilla, JavierGuarro, Josep
    Resum:
    Aspergillus fumigatus is the main mold causing invasive fungal infection that shows high mortality rates. Therapeutic failure and the increase in drug resistance make it necessary to explore alternative treatments for this infection. We have evaluated the efficacy of amphotericin B at 0.8 mg/kg or 0.3 mg/kg of body weight combined with 40 mg/kg of posaconazole against three A. fumigatus isolates in a murine model of disseminated infection. The combination of the polyene and the azole led to a greater increase in survival and a significantly greater reduction in tissue burden than monotherapies.
  • Altres:

    Autor segons l'article: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep;
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Capilla Luque, Javier / Guarro Artigas, Josep
    Paraules clau: Wild-type Voriconazole Transplant recipients Salvage therapy Resistance Model Invasive pulmonary aspergillosis Hematological malignancies Fumigatus Combination antifungal therapy
    Resum: Aspergillus fumigatus is the main mold causing invasive fungal infection that shows high mortality rates. Therapeutic failure and the increase in drug resistance make it necessary to explore alternative treatments for this infection. We have evaluated the efficacy of amphotericin B at 0.8 mg/kg or 0.3 mg/kg of body weight combined with 40 mg/kg of posaconazole against three A. fumigatus isolates in a murine model of disseminated infection. The combination of the polyene and the azole led to a greater increase in survival and a significantly greater reduction in tissue burden than monotherapies.
    Àrees temàtiques: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00664804
    Adreça de correu electrònic de l'autor: javier.capilla@urv.cat
    Identificador de l'autor: 0000-0002-0765-6403
    Data d'alta del registre: 2024-09-07
    Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
    Enllaç font original: https://journals.asm.org/doi/10.1128/aac.01462-15
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Antimicrobial Agents And Chemotherapy. 60 (1): 296-300
    Referència de l'ítem segons les normes APA: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep; (2016). In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis. Antimicrobial Agents And Chemotherapy, 60(1), 296-300. DOI: 10.1128/AAC.01462-15
    DOI de l'article: 10.1128/AAC.01462-15
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2016
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Infectious Diseases,Microbiology,Pharmacology,Pharmacology & Pharmacy,Pharmacology (Medical)
    Wild-type
    Voriconazole
    Transplant recipients
    Salvage therapy
    Resistance
    Model
    Invasive pulmonary aspergillosis
    Hematological malignancies
    Fumigatus
    Combination antifungal therapy
    Saúde coletiva
    Química
    Pharmacology (medical)
    Pharmacology & pharmacy
    Pharmacology
    Odontología
    Nutrição
    Microbiology
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Infectious diseases
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
  • Documents:

  • Cerca a google

    Search to google scholar