Autor segons l'article: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Capilla Luque, Javier / Guarro Artigas, Josep
Paraules clau: Wild-type; Voriconazole; Triazoles; Transplant recipients; Survival analysis; Sterol 14-demethylase; Salvage therapy; Resistance; Posaconazole; Model; Microbial sensitivity tests; Mice; Male; Lung; Kidney; Isoenzymes; Invasive pulmonary aspergillosis; Hematological malignancies; Gene expression; Fumigatus; Drug synergism; Drug resistance, fungal; Drug administration schedule; Combination antifungal therapy; Aspergillus fumigatus; Aspergillosis; Antifungal agents; Animals; Amphotericin b
Resum: Aspergillus fumigatus is the main mold causing invasive fungal infection that shows high mortality rates. Therapeutic failure and the increase in drug resistance make it necessary to explore alternative treatments for this infection. We have evaluated the efficacy of amphotericin B at 0.8 mg/kg or 0.3 mg/kg of body weight combined with 40 mg/kg of posaconazole against three A. fumigatus isolates in a murine model of disseminated infection. The combination of the polyene and the azole led to a greater increase in survival and a significantly greater reduction in tissue burden than monotherapies.
Àrees temàtiques: Saúde coletiva; Química; Pharmacology (medical); Pharmacology & pharmacy; Pharmacology; Odontología; Nutrição; Microbiology; Medicina veterinaria; Medicina iii; Medicina ii; Medicina i; Materiais; Matemática / probabilidade e estatística; Interdisciplinar; Infectious diseases; Farmacia; Ensino; Engenharias iv; Engenharias iii; Engenharias ii; Enfermagem; Educação física; Educação; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Astronomia / física
Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Adreça de correu electrònic de l'autor: javier.capilla@urv.cat
Data d'alta del registre: 2025-01-28
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://journals.asm.org/doi/10.1128/aac.01462-15
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
Referència a l'article segons font original: Antimicrobial Agents And Chemotherapy. 60 (1): 296-300
Referència de l'ítem segons les normes APA: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep (2016). In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis. Antimicrobial Agents And Chemotherapy, 60(1), 296-300. DOI: 10.1128/AAC.01462-15
DOI de l'article: 10.1128/AAC.01462-15
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2016
Tipus de publicació: Journal Publications
Repositori URV