Author, as appears in the article.: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep;
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep
Keywords: Wild-type Voriconazole Transplant recipients Salvage therapy Resistance Model Invasive pulmonary aspergillosis Hematological malignancies Fumigatus Combination antifungal therapy
Abstract: Aspergillus fumigatus is the main mold causing invasive fungal infection that shows high mortality rates. Therapeutic failure and the increase in drug resistance make it necessary to explore alternative treatments for this infection. We have evaluated the efficacy of amphotericin B at 0.8 mg/kg or 0.3 mg/kg of body weight combined with 40 mg/kg of posaconazole against three A. fumigatus isolates in a murine model of disseminated infection. The combination of the polyene and the azole led to a greater increase in survival and a significantly greater reduction in tissue burden than monotherapies.
Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Author's mail: javier.capilla@urv.cat
Author identifier: 0000-0002-0765-6403
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://journals.asm.org/doi/10.1128/aac.01462-15
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Antimicrobial Agents And Chemotherapy. 60 (1): 296-300
APA: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep; (2016). In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis. Antimicrobial Agents And Chemotherapy, 60(1), 296-300. DOI: 10.1128/AAC.01462-15
Article's DOI: 10.1128/AAC.01462-15
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications
Repositori URV