Articles producció científica> Ciències Mèdiques Bàsiques

In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis

  • Identification data

    Identifier: imarina:6063226
    Authors:
    Martin-Vicente, AdelaCapilla, JavierGuarro, Josep
    Abstract:
    Aspergillus fumigatus is the main mold causing invasive fungal infection that shows high mortality rates. Therapeutic failure and the increase in drug resistance make it necessary to explore alternative treatments for this infection. We have evaluated the efficacy of amphotericin B at 0.8 mg/kg or 0.3 mg/kg of body weight combined with 40 mg/kg of posaconazole against three A. fumigatus isolates in a murine model of disseminated infection. The combination of the polyene and the azole led to a greater increase in survival and a significantly greater reduction in tissue burden than monotherapies.
  • Others:

    Author, as appears in the article.: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep
    Keywords: Wild-type Voriconazole Triazoles Transplant recipients Survival analysis Sterol 14-demethylase Salvage therapy Resistance Posaconazole Model Microbial sensitivity tests Mice Male Lung Kidney Isoenzymes Invasive pulmonary aspergillosis Hematological malignancies Gene expression Fumigatus Drug synergism Drug resistance, fungal Drug administration schedule Combination antifungal therapy Aspergillus fumigatus Aspergillosis Antifungal agents Animals Amphotericin b
    Abstract: Aspergillus fumigatus is the main mold causing invasive fungal infection that shows high mortality rates. Therapeutic failure and the increase in drug resistance make it necessary to explore alternative treatments for this infection. We have evaluated the efficacy of amphotericin B at 0.8 mg/kg or 0.3 mg/kg of body weight combined with 40 mg/kg of posaconazole against three A. fumigatus isolates in a murine model of disseminated infection. The combination of the polyene and the azole led to a greater increase in survival and a significantly greater reduction in tissue burden than monotherapies.
    Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 00664804
    Author's mail: javier.capilla@urv.cat
    Author identifier: 0000-0002-0765-6403
    Record's date: 2025-01-28
    Paper version: info:eu-repo/semantics/acceptedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Paper original source: Antimicrobial Agents And Chemotherapy. 60 (1): 296-300
    APA: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep (2016). In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis. Antimicrobial Agents And Chemotherapy, 60(1), 296-300. DOI: 10.1128/AAC.01462-15
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2016
    Publication Type: Journal Publications
  • Keywords:

    Infectious Diseases,Microbiology,Pharmacology,Pharmacology & Pharmacy,Pharmacology (Medical)
    Wild-type
    Voriconazole
    Triazoles
    Transplant recipients
    Survival analysis
    Sterol 14-demethylase
    Salvage therapy
    Resistance
    Posaconazole
    Model
    Microbial sensitivity tests
    Mice
    Male
    Lung
    Kidney
    Isoenzymes
    Invasive pulmonary aspergillosis
    Hematological malignancies
    Gene expression
    Fumigatus
    Drug synergism
    Drug resistance, fungal
    Drug administration schedule
    Combination antifungal therapy
    Aspergillus fumigatus
    Aspergillosis
    Antifungal agents
    Animals
    Amphotericin b
    Saúde coletiva
    Química
    Pharmacology (medical)
    Pharmacology & pharmacy
    Pharmacology
    Odontología
    Nutrição
    Microbiology
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Infectious diseases
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Astronomia / física
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