Author, as appears in the article.: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Capilla Luque, Javier / Guarro Artigas, Josep
Keywords: Wild-type Voriconazole Triazoles Transplant recipients Survival analysis Sterol 14-demethylase Salvage therapy Resistance Posaconazole Model Microbial sensitivity tests Mice Male Lung Kidney Isoenzymes Invasive pulmonary aspergillosis Hematological malignancies Gene expression Fumigatus Drug synergism Drug resistance, fungal Drug administration schedule Combination antifungal therapy Aspergillus fumigatus Aspergillosis Antifungal agents Animals Amphotericin b
Abstract: Aspergillus fumigatus is the main mold causing invasive fungal infection that shows high mortality rates. Therapeutic failure and the increase in drug resistance make it necessary to explore alternative treatments for this infection. We have evaluated the efficacy of amphotericin B at 0.8 mg/kg or 0.3 mg/kg of body weight combined with 40 mg/kg of posaconazole against three A. fumigatus isolates in a murine model of disseminated infection. The combination of the polyene and the azole led to a greater increase in survival and a significantly greater reduction in tissue burden than monotherapies.
Thematic Areas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Author's mail: javier.capilla@urv.cat
Author identifier: 0000-0002-0765-6403
Record's date: 2025-01-28
Paper version: info:eu-repo/semantics/acceptedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Antimicrobial Agents And Chemotherapy. 60 (1): 296-300
APA: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep (2016). In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis. Antimicrobial Agents And Chemotherapy, 60(1), 296-300. DOI: 10.1128/AAC.01462-15
Entity: Universitat Rovira i Virgili
Journal publication year: 2016
Publication Type: Journal Publications