Autor según el artículo: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Capilla Luque, Javier / Guarro Artigas, Josep
Palabras clave: Wild-type Voriconazole Triazoles Transplant recipients Survival analysis Sterol 14-demethylase Salvage therapy Resistance Posaconazole Model Microbial sensitivity tests Mice Male Lung Kidney Isoenzymes Invasive pulmonary aspergillosis Hematological malignancies Gene expression Fumigatus Drug synergism Drug resistance, fungal Drug administration schedule Combination antifungal therapy Aspergillus fumigatus Aspergillosis Antifungal agents Animals Amphotericin b
Resumen: Aspergillus fumigatus is the main mold causing invasive fungal infection that shows high mortality rates. Therapeutic failure and the increase in drug resistance make it necessary to explore alternative treatments for this infection. We have evaluated the efficacy of amphotericin B at 0.8 mg/kg or 0.3 mg/kg of body weight combined with 40 mg/kg of posaconazole against three A. fumigatus isolates in a murine model of disseminated infection. The combination of the polyene and the azole led to a greater increase in survival and a significantly greater reduction in tissue burden than monotherapies.
Áreas temáticas: Saúde coletiva Química Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Nutrição Microbiology Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Infectious diseases Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 00664804
Direcció de correo del autor: javier.capilla@urv.cat
Identificador del autor: 0000-0002-0765-6403
Fecha de alta del registro: 2025-01-28
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Antimicrobial Agents And Chemotherapy. 60 (1): 296-300
Referencia de l'ítem segons les normes APA: Martin-Vicente, Adela; Capilla, Javier; Guarro, Josep (2016). In Vivo Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis. Antimicrobial Agents And Chemotherapy, 60(1), 296-300. DOI: 10.1128/AAC.01462-15
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Tipo de publicación: Journal Publications
Repositori URV