Autor segons l'article: Tran T; Wilson B; Henrich C; Wendt K; King J; Cichewicz R; Stchigel A; Miller A; O'Keefe B; Gustafson K
Departament: Ciències Mèdiques Bàsiques
Autor/s de la URV: Stchigel Glikman, Alberto Miguel
Paraules clau: Structure elucidation Mosher's ester analysis Dictyosporium digitatum Dictyosporin Dictyosporiaceae Dft calculations
Resum: © 2020 Following the discovery of a new class of compounds that inhibit the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) protease in a prior study, further chemical investigation of the Dictyosporium digitatum fungus resulted in the identification of 16 additional metabolites, including 12 undescribed compounds (1–12). The constitution and relative configuration of these new molecules were established by comprehensive NMR and HRMS analyses. Their absolute configurations were determined by employing Mosher's ester analysis and TDDFT ECD calculations. Two sesquiterpenes, dictyosporins A (1) and B (2), possess an undescribed eudesmen-type of structural scaffold. The ability of the isolated compounds to inhibit MALT1 proteolytic activity was evaluated, but none of them exhibited significant inhibition.
Àrees temàtiques: Química Plant sciences Plant science Odontología Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Interdisciplinar Horticulture General medicine Farmacia Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
Adreça de correu electrònic de l'autor: albertomiguel.stchigel@urv.cat
Identificador de l'autor: 0000-0003-3987-7996
Data d'alta del registre: 2023-02-19
Versió de l'article dipositat: info:eu-repo/semantics/acceptedVersion
Enllaç font original: https://www.sciencedirect.com/science/article/abs/pii/S0031942219307824?via%3Dihub
Referència a l'article segons font original: Phytochemistry. 173 (112278):
Referència de l'ítem segons les normes APA: Tran T; Wilson B; Henrich C; Wendt K; King J; Cichewicz R; Stchigel A; Miller A; O'Keefe B; Gustafson K (2020). Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods. Phytochemistry, 173(112278), -. DOI: 10.1016/j.phytochem.2020.112278
URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI de l'article: 10.1016/j.phytochem.2020.112278
Entitat: Universitat Rovira i Virgili
Any de publicació de la revista: 2020
Tipus de publicació: Journal Publications
Repositori URV