Autor según el artículo: Tran T; Wilson B; Henrich C; Wendt K; King J; Cichewicz R; Stchigel A; Miller A; O'Keefe B; Gustafson K
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Stchigel Glikman, Alberto Miguel
Palabras clave: Structure elucidation Mosher's ester analysis Dictyosporium digitatum Dictyosporin Dictyosporiaceae Dft calculations
Resumen: © 2020 Following the discovery of a new class of compounds that inhibit the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) protease in a prior study, further chemical investigation of the Dictyosporium digitatum fungus resulted in the identification of 16 additional metabolites, including 12 undescribed compounds (1–12). The constitution and relative configuration of these new molecules were established by comprehensive NMR and HRMS analyses. Their absolute configurations were determined by employing Mosher's ester analysis and TDDFT ECD calculations. Two sesquiterpenes, dictyosporins A (1) and B (2), possess an undescribed eudesmen-type of structural scaffold. The ability of the isolated compounds to inhibit MALT1 proteolytic activity was evaluated, but none of them exhibited significant inhibition.
Áreas temáticas: Química Plant sciences Plant science Odontología Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Interdisciplinar Horticulture General medicine Farmacia Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
Direcció de correo del autor: albertomiguel.stchigel@urv.cat
Identificador del autor: 0000-0003-3987-7996
Fecha de alta del registro: 2023-02-19
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0031942219307824?via%3Dihub
Referencia al articulo segun fuente origial: Phytochemistry. 173 (112278):
Referencia de l'ítem segons les normes APA: Tran T; Wilson B; Henrich C; Wendt K; King J; Cichewicz R; Stchigel A; Miller A; O'Keefe B; Gustafson K (2020). Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods. Phytochemistry, 173(112278), -. DOI: 10.1016/j.phytochem.2020.112278
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1016/j.phytochem.2020.112278
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV