Author, as appears in the article.: Tran T; Wilson B; Henrich C; Wendt K; King J; Cichewicz R; Stchigel A; Miller A; O'Keefe B; Gustafson K
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Stchigel Glikman, Alberto Miguel
Keywords: Structure elucidation Mosher's ester analysis Dictyosporium digitatum Dictyosporin Dictyosporiaceae Dft calculations
Abstract: © 2020 Following the discovery of a new class of compounds that inhibit the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) protease in a prior study, further chemical investigation of the Dictyosporium digitatum fungus resulted in the identification of 16 additional metabolites, including 12 undescribed compounds (1–12). The constitution and relative configuration of these new molecules were established by comprehensive NMR and HRMS analyses. Their absolute configurations were determined by employing Mosher's ester analysis and TDDFT ECD calculations. Two sesquiterpenes, dictyosporins A (1) and B (2), possess an undescribed eudesmen-type of structural scaffold. The ability of the isolated compounds to inhibit MALT1 proteolytic activity was evaluated, but none of them exhibited significant inhibition.
Thematic Areas: Química Plant sciences Plant science Odontología Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Interdisciplinar Horticulture General medicine Farmacia Engenharias ii Engenharias i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
Author's mail: albertomiguel.stchigel@urv.cat
Author identifier: 0000-0003-3987-7996
Record's date: 2023-02-19
Papper version: info:eu-repo/semantics/acceptedVersion
Papper original source: Phytochemistry. 173 (112278):
APA: Tran T; Wilson B; Henrich C; Wendt K; King J; Cichewicz R; Stchigel A; Miller A; O'Keefe B; Gustafson K (2020). Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods. Phytochemistry, 173(112278), -. DOI: 10.1016/j.phytochem.2020.112278
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2020
Publication Type: Journal Publications
Repositori URV