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Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?

  • Dades identificatives

    Identificador: imarina:6310799
    Autors:
    Roedel, FranzArenas, MeritxellOtt, Oliver JFournier, ClaudiaGeorgakilas, Alexandros GTapio, SoileTrott, Klaus-RuedigerGaipl, Udo S
    Resum:
    In the current dismal situation of the COVID-19 pandemic, effective management of patients with pneumonia and acute respiratory distress syndrome is of vital importance. Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 & x202f;Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 & x202f;Gy. This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation.
  • Altres:

    Autor segons l'article: Roedel, Franz; Arenas, Meritxell; Ott, Oliver J; Fournier, Claudia; Georgakilas, Alexandros G; Tapio, Soile; Trott, Klaus-Ruediger; Gaipl, Udo S
    Departament: Ciències Mèdiques Bàsiques
    Autor/s de la URV: Arenas Prat, Meritxell
    Paraules clau: Sars-cov-2 Repair Radiotherapy Pneumonia Low-dose radiation therapy Induction Covid-19 Anti-inflammatory pneumonia low-dose radiation therapy covid-19 anti-inflammatory
    Resum: In the current dismal situation of the COVID-19 pandemic, effective management of patients with pneumonia and acute respiratory distress syndrome is of vital importance. Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 & x202f;Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 & x202f;Gy. This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation.
    Àrees temàtiques: Radiology, nuclear medicine and imaging Radiology, nuclear medicine & medical imaging Oncology General medicine
    Accès a la llicència d'ús: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 1439099X
    Adreça de correu electrònic de l'autor: meritxell.arenas@urv.cat
    Identificador de l'autor: https://orcid.org/0000-0003-0815-2570 0000-0003-0815-2570
    Data d'alta del registre: 2025-03-15
    Versió de l'article dipositat: info:eu-repo/semantics/publishedVersion
    URL Document de llicència: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referència a l'article segons font original: Strahlentherapie Und Onkologie. 196 (8): 679-682
    Referència de l'ítem segons les normes APA: Roedel, Franz; Arenas, Meritxell; Ott, Oliver J; Fournier, Claudia; Georgakilas, Alexandros G; Tapio, Soile; Trott, Klaus-Ruediger; Gaipl, Udo S (2020). Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?. Strahlentherapie Und Onkologie, 196(8), 679-682. DOI: 10.1007/s00066-020-01635-7
    Entitat: Universitat Rovira i Virgili
    Any de publicació de la revista: 2020
    Tipus de publicació: Journal Publications
  • Paraules clau:

    Oncology,Radiology, Nuclear Medicine & Medical Imaging,Radiology, Nuclear Medicine and Imaging
    Sars-cov-2
    Repair
    Radiotherapy
    Pneumonia
    Low-dose radiation therapy
    Induction
    Covid-19
    Anti-inflammatory
    pneumonia
    low-dose radiation therapy
    covid-19
    anti-inflammatory
    Radiology, nuclear medicine and imaging
    Radiology, nuclear medicine & medical imaging
    Oncology
    General medicine
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